bmp5 bone morphogenetic protein 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmp5provided by ZNC
Official Full Name: bone morphogenetic protein 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1413
See related: Ensembl:ENSDARG00000101701 AllianceGenome:ZFIN:ZDB-GENE-040426-1413
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bmp5l; zehl0669; zgc:64230; hm:zehl0669
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Acts upstream of or within neural crest cell development; positive regulation of ERK1 and ERK2 cascade; and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including neural crest; optic vesicle; periderm; pharyngeal arch; and sensory system. Orthologous to human BMP5 (bone morphogenetic protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (1872769..1906735)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (1741478..1775444)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

zebrafish bmp5 is expressed in neural crest progenitor cells and it activates the Smad and Erk signaling pathways to regulate cell survival and proliferation, respectively.
Title: Bmp5 Regulates Neural Crest Cell Survival and Proliferation via Two Different Signaling Pathways.
Results identify bone morphogenetic proteins 2b and 5 as crucial components of the endodermal signals that induce epibranchial neurogenesis.
Title: Requirements for endoderm and BMP signaling in sensory neurogenesis in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201051.1 → NP_957345.1 bone morphogenetic protein 5 precursor

See identical proteins and their annotated locations for NP_957345.1

Status: PROVISIONAL

Source sequence(s)

BC054647

UniProtKB/TrEMBL

Q7T288

Related

ENSDARP00000134612.1, ENSDART00000161162.3

Conserved Domains (2) summary

pfam00019
Location:343 → 445

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:23 → 295

TGFb_propeptide; TGF-beta propeptide