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nek2 NIMA-related kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 394025, updated on 27-Mar-2024

Summary

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Official Symbol
nek2provided by ZNC
Official Full Name
NIMA-related kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-752
See related
Ensembl:ENSDARG00000005619 AllianceGenome:ZFIN:ZDB-GENE-040426-752
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55602
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within retinal rod cell development. Predicted to be active in centrosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (13883165..13893910)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (13987185..13997930)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene opsin 8, group member c Neighboring gene lysophosphatidylglycerol acyltransferase 1 Neighboring gene solute carrier family 30 member 1a Neighboring gene si:dkey-249p7.4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene. Nishiguchi KM, et al. Proc Natl Acad Sci U S A, 2013 Oct 1. PMID 24043777, Free PMC Article
  2. Characterization and development of novel small-molecules inhibiting GSK3 and activating Wnt signaling. Zhong H, et al. Mol Biosyst, 2009 Nov. PMID 19823752, Free PMC Article
  3. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC55602

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retinal rod cell development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retinal rod cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek2
Names
NIMA (never in mitosis gene a)-related kinase 2
NP_957344.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201050.1 → NP_957344.1  serine/threonine-protein kinase Nek2

    See identical proteins and their annotated locations for NP_957344.1

    Status: PROVISIONAL

    Source sequence(s)
    BC048055
    UniProtKB/TrEMBL
    A0A2R8Q6P9, F6P194, Q7ZUN2
    Related
    ENSDARP00000020452.5, ENSDART00000003248.8
    Conserved Domains (2) summary
    smart00220
    Location:8 → 267
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7 → 271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    13883165..13893910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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