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fbxo32 F-box protein 32 [ Danio rerio (zebrafish) ]

Gene ID: 393891, updated on 27-Mar-2024

Summary

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Official Symbol
fbxo32provided by ZNC
Official Full Name
F-box protein 32provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1040
See related
Ensembl:ENSDARG00000040277 AllianceGenome:ZFIN:ZDB-GENE-040426-1040
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
atrogin1; zgc:56479
Summary
Acts upstream of or within several processes, including cardiac muscle tissue morphogenesis; heart contraction; and muscle cell cellular homeostasis. Located in cytoplasm. Is expressed in cardiac muscle cell; muscle; skeletal muscle cell; and yolk syncytial layer. Orthologous to human FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25259313..25272633)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25344281..25357601)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene LRAT domain containing 2b Neighboring gene kelch-like family member 38b Neighboring gene PRELI domain containing 3A Neighboring gene si:dkey-29h14.10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Assessment of the Preventive Effect of L-carnitine on Post-statin Muscle Damage in a Zebrafish Model. Niedbalska-Tarnowska J, et al. Cells, 2022 Apr 11. PMID 35455976, Free PMC Article
  2. Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio). Pasha R, et al. Environ Toxicol Pharmacol, 2017 Jun. PMID 28414942
  3. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. Cao P, et al. FASEB J, 2009 Sep. PMID 19406843, Free PMC Article
  4. Molecular characterization of atrogin-1/F-box protein-32 (FBXO32) and F-box protein-25 (FBXO25) in rainbow trout (Oncorhynchus mykiss): Expression across tissues in response to feed deprivation. Cleveland BM, et al. Comp Biochem Physiol B Biochem Mol Biol, 2010 Nov. PMID 20601059
  5. Depletion of Foxk transcription factors causes genome-wide transcriptional misregulation and developmental arrest in zebrafish embryos. Geng FS, et al. MicroPubl Biol, 2020 Dec 8. PMID 33313487, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56479

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
F-box only protein 32
Names
atrogin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200917.1 → NP_957211.1  F-box only protein 32

    See identical proteins and their annotated locations for NP_957211.1

    Status: PROVISIONAL

    Source sequence(s)
    BC052112
    UniProtKB/TrEMBL
    Q7ZTY2
    Related
    ENSDARP00000058937.4, ENSDART00000058938.5
    Conserved Domains (2) summary
    pfam06881
    Location:254 → 303
    Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A
    pfam12937
    Location:226 → 272
    F-box-like; F-box-like

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    25259313..25272633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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