scp2a sterol carrier protein 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scp2aprovided by ZNC
Official Full Name: sterol carrier protein 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1846
See related: Ensembl:ENSDARG00000012194 AllianceGenome:ZFIN:ZDB-GENE-040426-1846
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: scp2; zgc:77634
Summary: Predicted to enable lipid binding activity; propanoyl-CoA C-acyltransferase activity; and propionyl-CoA C2-trimethyltridecanoyltransferase activity. Predicted to be involved in positive regulation of intracellular cholesterol transport. Predicted to act upstream of or within lipid transport. Predicted to be located in mitochondrion and peroxisome. Is expressed in intestinal bulb; lens; liver; and solid lens vesicle. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (6005199..6039741, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (6093317..6127859, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables propanoyl-CoA C-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: non-specific lipid-transfer protein; sterol carrier protein 2

NP_957159.1

EC 2.3.1.176

XP_005163287.2

EC 2.3.1.176

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200865.2 → NP_957159.1 sterol carrier protein 2

See identical proteins and their annotated locations for NP_957159.1

Status: VALIDATED

Source sequence(s)

BC063230, EB893297

UniProtKB/TrEMBL

A0A8M1PDK4, Q6P4V5

Related

ENSDARP00000009052.7, ENSDART00000013079.9

Conserved Domains (3) summary

PRK08256
Location:6 → 397

PRK08256; lipid-transfer protein; Provisional

cd00826
Location:11 → 396

nondecarbox_cond_enzymes; nondecarboxylating condensing enzymes; In general, thiolases catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. There are 2 ...

pfam02036
Location:428 → 529

SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

6005199..6039741 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163230.2 → XP_005163287.2 non-specific lipid-transfer protein isoform X1

UniProtKB/TrEMBL

A0A8M2BA96

Conserved Domains (2) summary

pfam02036
Location:222 → 323

SCP2; SCP-2 sterol transfer family

cl27752
Location:1 → 191

PRK06064; acetyl-CoA acetyltransferase; Provisional