dnajc19 DnaJ (Hsp40) homolog, subfamily C, member 19 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dnajc19provided by ZNC
Official Full Name: DnaJ (Hsp40) homolog, subfamily C, member 19provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1730
See related: Ensembl:ENSDARG00000044420 AllianceGenome:ZFIN:ZDB-GENE-040426-1730
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73251
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix and regulation of cardiolipin metabolic process. Predicted to act upstream of or within protein transport. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. Is expressed in heart. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (37534134..37540616)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (37599216..37605698)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiolipin metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
part_of inner mitochondrial membrane protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in matrix side of mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit TIM14

Names: dnaJ homolog subfamily C member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200761.1 → NP_957055.1 mitochondrial import inner membrane translocase subunit TIM14

See identical proteins and their annotated locations for NP_957055.1

Status: PROVISIONAL

Source sequence(s)

BC059589

UniProtKB/Swiss-Prot

Q6PBT7

Related

ENSDARP00000065238.5, ENSDART00000065239.6

Conserved Domains (1) summary

cl02542
Location:5 → 109

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...