hsbp1b heat shock factor binding protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsbp1bprovided by ZNC
Official Full Name: heat shock factor binding protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1721
See related: Ensembl:ENSDARG00000041921 AllianceGenome:ZFIN:ZDB-GENE-040426-1721
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsbp1; zgc:73224
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within central nervous system development and neural crest formation. Is expressed in head. Orthologous to human HSBP1 (heat shock factor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (14334254..14337467, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (14365742..14368952, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSBP1 plays an essential role during early mouse and zebrafish embryonic development; lack of hsbp1 in embryoid bodies leads to disorganization of the germ layers and a reduction in the endoderm-specific markers.
Title: An essential role for heat shock transcription factor binding protein 1 (HSBP1) during early embryonic development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular heat acclimation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock factor-binding protein 1b

Names: heat shock factor binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.