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phactr4b phosphatase and actin regulator 4b [ Danio rerio (zebrafish) ]

Gene ID: 393643, updated on 27-Mar-2024

Summary

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Official Symbol
phactr4bprovided by ZNC
Official Full Name
phosphatase and actin regulator 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1131
See related
Ensembl:ENSDARG00000032221 AllianceGenome:ZFIN:ZDB-GENE-040426-1131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
phactr4; zgc:63484
Summary
Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Predicted to be involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Predicted to act upstream of or within nervous system development. Predicted to be located in lamellipodium. Is expressed in Purkinje cell. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 16
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (34198025..34285185, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (34243995..34331144, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1b Neighboring gene regulator of chromosome condensation 1 Neighboring gene endothelin-2-like Neighboring gene transcription factor HIVEP3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63484

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase 1 binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 1 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in closure of optic fissure IEA
Inferred from Electronic Annotation
more info
  
involved_in closure of optic fissure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in enteric nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in enteric nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural crest cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural tube closure IEA
Inferred from Electronic Annotation
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphatase and actin regulator 4B
Names
phosphatase and actin regulator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200670.1 → NP_956964.1  phosphatase and actin regulator 4B

    See identical proteins and their annotated locations for NP_956964.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058052
    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    Related
    ENSDARP00000044234.6, ENSDART00000044235.8
    Conserved Domains (2) summary
    smart00707
    Location:637 → 660
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 84
    RPEL; RPEL repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    34198025..34285185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292434.3 → XP_009290709.1  phosphatase and actin regulator 4B isoform X5

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M3B1T3
    Conserved Domains (2) summary
    smart00707
    Location:693 → 716
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 84
    RPEL; RPEL repeat

  2. XM_005158334.4 → XP_005158391.1  phosphatase and actin regulator 4B isoform X3

    See identical proteins and their annotated locations for XP_005158391.1

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M3AI89
    Conserved Domains (2) summary
    smart00707
    Location:737 → 760
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 84
    RPEL; RPEL repeat

  3. XM_009292432.3 → XP_009290707.1  phosphatase and actin regulator 4B isoform X3

    See identical proteins and their annotated locations for XP_009290707.1

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M3AI89
    Conserved Domains (2) summary
    smart00707
    Location:737 → 760
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 84
    RPEL; RPEL repeat

  4. XM_021466650.1 → XP_021322325.1  phosphatase and actin regulator 4B isoform X3

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M3AI89
    Conserved Domains (2) summary
    smart00707
    Location:737 → 760
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:62 → 84
    RPEL; RPEL repeat

  5. XM_005158332.4 → XP_005158389.1  phosphatase and actin regulator 4B isoform X1

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M2B587
    Conserved Domains (2) summary
    smart00707
    Location:751 → 774
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:76 → 98
    RPEL; RPEL repeat

  6. XM_005158335.4 → XP_005158392.1  phosphatase and actin regulator 4B isoform X4

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M2B4R2
    Conserved Domains (2) summary
    smart00707
    Location:707 → 730
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:76 → 98
    RPEL; RPEL repeat

  7. XM_005158333.4 → XP_005158390.1  phosphatase and actin regulator 4B isoform X2

    UniProtKB/Swiss-Prot
    F1QNE2, Q6PEI3
    UniProtKB/TrEMBL
    A0A8M2B574
    Conserved Domains (2) summary
    smart00707
    Location:748 → 771
    RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
    pfam02755
    Location:73 → 95
    RPEL; RPEL repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PEI3.2 GenPept UniProtKB/Swiss-Prot:Q6PEI3

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