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ptpn12 protein tyrosine phosphatase non-receptor type 12 [ Danio rerio (zebrafish) ]

Gene ID: 393642, updated on 11-Apr-2024

Summary

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Official Symbol
ptpn12provided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 12provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1441
See related
Ensembl:ENSDARG00000102141 AllianceGenome:ZFIN:ZDB-GENE-040426-1441
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:65856; zgc:77437
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasm. Is expressed in several structures, including immature eye; nervous system; neural tube; pectoral fin musculature; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ptpn12 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (17307..20765, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (248648..252106)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor ionotropic, kainate 2-like Neighboring gene putative homeodomain transcription factor 2 Neighboring gene proline rich 5b (renal)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mosaic partial deletion of PTPN12 in a child with interrupted aortic arch type A. Duffy EA, et al. Am J Med Genet A, 2015 Nov. PMID 26250342
  2. Differential oxidation of protein-tyrosine phosphatases during zebrafish caudal fin regeneration. Wu W, et al. Sci Rep, 2017 Aug 16. PMID 28814789, Free PMC Article
  3. A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio). McPartland JM, et al. Mol Genet Genomics, 2007 May. PMID 17256142
  4. Zebrafish as a model to study PTPs during development. Paardekooper Overman J, et al. Methods, 2014 Jan 15. PMID 23974070
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC65856

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 12
NP_956963.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200669.1 → NP_956963.1  tyrosine-protein phosphatase non-receptor type 12

    See identical proteins and their annotated locations for NP_956963.1

    Status: PROVISIONAL

    Source sequence(s)
    BC058051
    UniProtKB/TrEMBL
    Q6PEI4
    Related
    ENSDARP00000130978.1, ENSDART00000171737.2
    Conserved Domains (2) summary
    cd00047
    Location:57 → 289
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:55 → 289
    Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    17307..20765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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