snx27b sorting nexin 27b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: snx27bprovided by ZNC
Official Full Name: sorting nexin 27bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1529
See related: Ensembl:ENSDARG00000016977 AllianceGenome:ZFIN:ZDB-GENE-040426-1529
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: snx27; zgc:66094; zgc:77922
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within endosomal transport and signal transduction. Predicted to be located in endosome and membrane. Predicted to be active in early endosome. Orthologous to human SNX27 (sorting nexin 27). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (23495561..23527558)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (23580534..23610700)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sorting nexin family member 27b; sorting nexin-27b

Names: sorting nexin family member 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200540.1 → NP_956834.1 sorting nexin-27b

See identical proteins and their annotated locations for NP_956834.1

Status: PROVISIONAL

Source sequence(s)

BC056315

UniProtKB/TrEMBL

Q6P3G2, Q6PHV2

Related

ENSDARP00000011221.8, ENSDART00000021092.9

Conserved Domains (4) summary

cd06886
Location:165 → 270

PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27

cd01777
Location:279 → 365

SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)

cd00992
Location:46 → 138

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13338
Location:430 → 531

FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

23495561..23527558

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158092.4 → XP_005158149.1 sorting nexin family member 27b isoform X1

UniProtKB/TrEMBL

A0A8M2B4E4

Conserved Domains (4) summary

cd06886
Location:165 → 270

PX_SNX27; The phosphoinositide binding Phox Homology domain of Sorting Nexin 27

cd01777
Location:279 → 365

SNX27_RA; Ubiquitin domain of SNX27 (sorting nexin protein 27)

cd00992
Location:46 → 138

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13338
Location:430 → 531

FERM-like_C_SNX27; Atypical FERM-like domain C-lobe of Sorting nexin 27