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asl argininosuccinate lyase [ Danio rerio (zebrafish) ]

Gene ID: 393423, updated on 27-Mar-2024

Summary

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Official Symbol
aslprovided by ZNC
Official Full Name
argininosuccinate lyaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1152
See related
Ensembl:ENSDARG00000033361 AllianceGenome:ZFIN:ZDB-GENE-040426-1152
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63532
Summary
Predicted to enable argininosuccinate lyase activity. Predicted to be involved in arginine biosynthetic process via ornithine. Predicted to be active in cytosol. Is expressed in several structures, including ball; lens; liver; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See asl in Genome Data Viewer
Location:
chromosome: 21
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (31253145..31274479)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (31216463..31237784)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene tyrosylprotein sulfotransferase 1, like Neighboring gene calcitonin gene-related peptide-receptor component protein Neighboring gene carbonic anhydrase IV c Neighboring gene teneurin transmembrane protein 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ontogeny of ornithine-urea cycle gene expression in zebrafish (Danio rerio). LeMoine CM, et al. Am J Physiol Regul Integr Comp Physiol, 2013 Jun 1. PMID 23576614
  2. l-aspartic acid promotes fish survival against Vibrio alginolyticus infection through nitric oxide-induced phagocytosis. Gong Q, et al. Fish Shellfish Immunol, 2020 Feb. PMID 31866447
  3. Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. Caldovic L, et al. PLoS One, 2014. PMID 24465614, Free PMC Article
  4. Malate enhances survival of zebrafish against Vibrio alginolyticus infection in the same manner as taurine. Yang MJ, et al. Virulence, 2020 Dec. PMID 32316833, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63532

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables argininosuccinate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables argininosuccinate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within arginine biosynthetic process via ornithine IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
argininosuccinate lyase
NP_956745.1
XP_005161350.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200451.1 → NP_956745.1  argininosuccinate lyase

    See identical proteins and their annotated locations for NP_956745.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055132
    UniProtKB/TrEMBL
    Q7SY44
    Related
    ENSDARP00000040189.6, ENSDART00000040190.7
    Conserved Domains (2) summary
    cd01359
    Location:28 → 460
    Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    PLN02646
    Location:2 → 464
    PLN02646; argininosuccinate lyase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    31253145..31274479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161293.4 → XP_005161350.1  argininosuccinate lyase isoform X1

    UniProtKB/TrEMBL
    A0A8M2B8A1, F1RA91
    Related
    ENSDARP00000143521.1, ENSDART00000178521.2
    Conserved Domains (2) summary
    cd01359
    Location:28 → 460
    Argininosuccinate_lyase; Argininosuccinate lyase (argininosuccinase, ASAL)
    PLN02646
    Location:2 → 464
    PLN02646; argininosuccinate lyase
Nucleotide Protein Strain
Heading Accession and Version

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