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pias4b protein inhibitor of activated STAT, 4b [ Danio rerio (zebrafish) ]

Gene ID: 393314, updated on 11-Apr-2024

Summary

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Official Symbol
pias4bprovided by ZNC
Official Full Name
protein inhibitor of activated STAT, 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1298
See related
Ensembl:ENSDARG00000042215 AllianceGenome:ZFIN:ZDB-GENE-040426-1298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pias4l; zgc:63923; wu:fi26h11
Summary
Predicted to enable SUMO ligase activity and transcription coregulator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57447105..57476462, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (57312951..57342308, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene transcription factor 3a Neighboring gene mitogen-activated protein kinase kinase 2b Neighboring gene one cut homeobox 3b Neighboring gene leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of a PIAS4 homologue from zebrafish: insights into its conserved negative regulatory mechanism in the TRIF, MAVS, and IFN signaling pathways during vertebrate evolution. Xiong R, et al. J Immunol, 2012 Mar 15. PMID 22345667
  2. Early depletion of primordial germ cells in zebrafish promotes testis formation. Tzung KW, et al. Stem Cell Reports, 2015 Jan 13. PMID 25434820, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63923

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 SUMO-protein ligase PIAS4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242942.1 → NP_001229871.1  E3 SUMO-protein ligase PIAS4b isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    CABZ01044182, EH491696, EH543530, EH570193
    UniProtKB/TrEMBL
    A0A2R8Q3K8, A0A8M1P1Y4
    Related
    ENSDARP00000145407.1, ENSDART00000192201.1
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:273 → 320
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:91 → 220
    PINIT; PINIT domain

  2. NM_200343.2 → NP_956637.2  E3 SUMO-protein ligase PIAS4b isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    EH491696, EH543530, EH570193
    UniProtKB/TrEMBL
    A0A8N1TYF8, F8W4B9
    Related
    ENSDARP00000124244.1, ENSDART00000150034.3
    Conserved Domains (3) summary
    smart00513
    Location:42 → 76
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:313 → 360
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:131 → 260
    PINIT; PINIT domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    57447105..57476462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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