fzr1a fizzy/cell division cycle 20 related 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fzr1aprovided by ZNC
Official Full Name: fizzy/cell division cycle 20 related 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-712
See related: Ensembl:ENSDARG00000015254 AllianceGenome:ZFIN:ZDB-GENE-040426-712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fzr1; zgc:55450
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process and positive regulation of anaphase-promoting complex-dependent catabolic process. Predicted to act upstream of or within cell division and positive regulation of ubiquitin protein ligase activity. Predicted to be part of anaphase-promoting complex. Orthologous to human FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (20863071..20876562)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (20830986..20844477)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fd03g06.y1 (e-PCR)
- UniSTS:194891

fj90g04.x1 (e-PCR)
- UniSTS:200291

fb72g06.y1 (e-PCR)
- UniSTS:191119

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fizzy/cell division cycle 20 related 1a

Names: fizzy/cell division cycle 20 related 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200253.1 → NP_956547.1 fizzy/cell division cycle 20 related 1a

See identical proteins and their annotated locations for NP_956547.1

Status: PROVISIONAL

Source sequence(s)

BC048038

UniProtKB/TrEMBL

B2GS30, Q7ZUP9

Related

ENSDARP00000003004.8, ENSDART00000015891.10

Conserved Domains (3) summary

COG2319
Location:143 → 492

WD40; WD40 repeat [General function prediction only]

cd00200
Location:195 → 473

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:234 → 271

7WD40; WD40 repeat [structural motif]