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erap1b endoplasmic reticulum aminopeptidase 1b [ Danio rerio (zebrafish) ]

Gene ID: 393175, updated on 27-Mar-2024

Summary

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Official Symbol
erap1bprovided by ZNC
Official Full Name
endoplasmic reticulum aminopeptidase 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-934
See related
Ensembl:ENSDARG00000021859 AllianceGenome:ZFIN:ZDB-GENE-040426-934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ARTS-1; zgc:56194
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including peptide catabolic process; proteolysis; and regulation of blood pressure. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 5
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26234404..26247688, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25634269..25647518, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene occludin b Neighboring gene general transcription factor IIH, polypeptide 2 Neighboring gene N-acetylated alpha-linked acidic dipeptidase like 1 Neighboring gene ARVCF delta catenin family member b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56194

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
endoplasmic reticulum aminopeptidase 1; endoplasmic reticulum aminopeptidase 1b
Names
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
NP_956500.2
XP_005171857.1
XP_009299728.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200206.2 → NP_956500.2  endoplasmic reticulum aminopeptidase 1b precursor

    Status: VALIDATED

    Source sequence(s)
    BX510923
    UniProtKB/TrEMBL
    A0A8M1PE71
    Related
    ENSDARP00000115928.1, ENSDART00000145187.3
    Conserved Domains (3) summary
    cd09601
    Location:54 → 548
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:46 → 453
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:615 → 932
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    26234404..26247688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171800.4 → XP_005171857.1  endoplasmic reticulum aminopeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_005171857.1

    UniProtKB/TrEMBL
    A0A8M3B9L5, F1QFR6
    Conserved Domains (3) summary
    cd09601
    Location:54 → 528
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:46 → 433
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:595 → 912
    ERAP1_C; ERAP1-like C-terminal domain

  2. XM_009301453.3 → XP_009299728.1  endoplasmic reticulum aminopeptidase 1 isoform X1

    See identical proteins and their annotated locations for XP_009299728.1

    UniProtKB/TrEMBL
    A0A8M3B9L5, F1QFR6
    Related
    ENSDARP00000089298.4, ENSDART00000098527.6
    Conserved Domains (3) summary
    cd09601
    Location:54 → 528
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:46 → 433
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:595 → 912
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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