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Zbtb42 zinc finger and BTB domain containing 42 [ Mus musculus (house mouse) ]

Gene ID: 382639, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb42provided by MGI
Official Full Name
zinc finger and BTB domain containing 42provided by MGI
Primary source
MGI:MGI:3644133
See related
Ensembl:ENSMUSG00000037638 AllianceGenome:MGI:3644133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm5188; EG382639; simiRP58
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ZBTB42 (zinc finger and BTB domain containing 42). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 17.1), colon adult (RPKM 15.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 F1; 12 61.2 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112645042..112649181)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112678648..112682747)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thymoma viral proto-oncogene 1 Neighboring gene microRNA 6939 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113913641-113913750 Neighboring gene predicted gene, 30150 Neighboring gene predicted gene, 30298 Neighboring gene predicted gene, 30238 Neighboring gene predicted gene, 46382 Neighboring gene centrosomal protein 170B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the ZBTB42 gene in humans and mice. Devaney SA, et al. Hum Genet, 2011 Apr. PMID 21193930, Free PMC Article
  2. Co-localization of a novel transcriptional repressor simiRP58 with RP58. Takahashi A, et al. Biochem Biophys Res Commun, 2008 Apr 11. PMID 18262495
  3. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in muscle organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 42
Names
protein simiRP58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100460.1 → NP_001093930.1  zinc finger and BTB domain-containing protein 42

    See identical proteins and their annotated locations for NP_001093930.1

    Status: VALIDATED

    Source sequence(s)
    AC124373
    Consensus CDS
    CCDS49190.1
    UniProtKB/Swiss-Prot
    Q811H0
    Related
    ENSMUSP00000133152.2, ENSMUST00000169593.2
    Conserved Domains (5) summary
    smart00225
    Location:25 → 121
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:334 → 388
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 354
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:14 → 114
    BTB; BTB/POZ domain
    pfam13465
    Location:347 → 369
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    112645042..112649181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516052.5 → XP_006516115.1  zinc finger and BTB domain-containing protein 42 isoform X1

    See identical proteins and their annotated locations for XP_006516115.1

    Conserved Domains (5) summary
    PLN02328
    Location:97 → 164
    PLN02328; lysine-specific histone demethylase 1 homolog
    COG5048
    Location:252 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl38908
    Location:1 → 47
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam13465
    Location:265 → 287
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811H0.2 GenPept UniProtKB/Swiss-Prot:Q811H0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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