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ABCB7 ATP binding cassette subfamily B member 7 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38193, updated on 10-May-2024

Summary

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Official Symbol
ABCB7provided by FlyBase
Official Full Name
ATP binding cassette subfamily B member 7provided by FlyBase
Primary source
FLYBASE:FBgn0035244
Locus tag
Dmel_CG7955
See related
AllianceGenome:FB:FBgn0035244
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7955; dABCB7; DmCG7955; Dmel\CG7955
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in cellular iron ion homeostasis; iron-sulfur cluster assembly; and iron-sulfur cluster export from the mitochondrion. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
62A8-62A9; 3-0.5 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1618414..1623413)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1618414..1623413)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45814 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene gamma-glutamyl carboxylase Neighboring gene uncharacterized protein Neighboring gene neuronal Synaptobrevin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. Sooksa-Nguan T, et al. J Biol Chem, 2009 Jan 2. PMID 19001374
  2. Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Sun H, et al. Insect Biochem Mol Biol, 2017 Oct. PMID 28803989
  3. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Bergmann AK, et al. Pediatr Blood Cancer, 2010 Feb. PMID 19731322, Free PMC Article
  4. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Metzendorf C, et al. Biochem J, 2009 Jul 15. PMID 19453295
  5. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Navarro JA, et al. Free Radic Biol Med, 2015 Aug. PMID 25841783

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. No ABCB7 mutations were found among sixty CSA probands examined
    Title: Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in iron-sulfur cluster export from the mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ATP binding cassette subfamily B member 7
Names
ABCB7-PA
ABCB7-PB
CG7955-PA
CG7955-PB
NP_728642.2
NP_728643.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1618414..1623413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167902.2 → NP_728642.2  ATP binding cassette subfamily B member 7, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728642.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDP0, Q9W0C5
    Related
    FBpp0072637
    Conserved Domains (3) summary
    COG5265
    Location:222 → 717
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:164 → 437
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:485 → 720
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_167903.2 → NP_728643.2  ATP binding cassette subfamily B member 7, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728643.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E6PBW9, Q7KVB1
    Related
    FBpp0072638
    Conserved Domains (3) summary
    COG5265
    Location:188 → 683
    ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
    cl00549
    Location:130 → 403
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:451 → 686
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KVA9 Q7KVA9
Q7KVB1 Q7KVB1
Q9W0C5 Q9W0C5

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