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Smim10l1 small integral membrane protein 10 like 1 [ Mus musculus (house mouse) ]

Gene ID: 381820, updated on 5-Mar-2024

Summary

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Official Symbol
Smim10l1provided by MGI
Official Full Name
small integral membrane protein 10 like 1provided by MGI
Primary source
MGI:MGI:1914379
See related
Ensembl:ENSMUSG00000072704 AllianceGenome:MGI:1914379
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700089E24Rik
Summary
Orthologous to several human genes including SMIM10 (small integral membrane protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.1), ovary adult (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Smim10l1 in Genome Data Viewer
Location:
6 G1; 6 64.03 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (133082202..133087862)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (133099150..133112089)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17520 Neighboring gene taste receptor, type 2, member 141, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E11338 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene calmodulin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17521 Neighboring gene STARR-seq mESC enhancer starr_17522 Neighboring gene RIKEN cDNA 5530400C23 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
small integral membrane protein 10-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163445.2 → NP_001156917.1  small integral membrane protein 10-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon structure in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC122520, AK077261, AW546677
    Consensus CDS
    CCDS51934.1
    UniProtKB/TrEMBL
    A0A087WPM1, E9Q3K4
    Related
    ENSMUSP00000098428.5, ENSMUST00000100864.7
    Conserved Domains (1) summary
    pfam15118
    Location:4 → 67
    DUF4560; Domain of unknown function (DUF4560)

  2. NM_001271582.1 → NP_001258511.1  small integral membrane protein 10-like protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AA048533, AC122520, BB868819
    UniProtKB/TrEMBL
    A0A087WPM1
    Conserved Domains (1) summary
    pfam15118
    Location:4 → 67
    DUF4560; Domain of unknown function (DUF4560)

  3. NM_001271583.1 → NP_001258512.1  small integral membrane protein 10-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA048533, AC122520
    Consensus CDS
    CCDS80626.1
    UniProtKB/TrEMBL
    A0A087WNQ7
    Related
    ENSMUSP00000139452.2, ENSMUST00000191462.2
    Conserved Domains (1) summary
    pfam15118
    Location:4 → 64
    DUF4560; Domain of unknown function (DUF4560)

RNA

  1. NR_073368.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA048533, AC122520
    Related
    ENSMUST00000187237.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    133082202..133087862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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