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4921509C19Rik RIKEN cDNA 4921509C19 gene [ Mus musculus (house mouse) ]

Gene ID: 381393, updated on 11-Apr-2024

Summary

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Official Symbol
4921509C19Rikprovided by MGI
Official Full Name
RIKEN cDNA 4921509C19 geneprovided by MGI
Primary source
MGI:MGI:2685851
See related
Ensembl:ENSMUSG00000061525 AllianceGenome:MGI:2685851
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1005
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in testis. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 29.3) See more
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Genomic context

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Location:
2 G3; 2 74.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (151302301..151318188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (151462048..151476268, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100125594 Neighboring gene predicted gene, 24868 Neighboring gene tubulin, alpha 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_06030 Neighboring gene STARR-positive B cell enhancer ABC_E11168 Neighboring gene NSFL1 (p97) cofactor (p47) Neighboring gene predicted gene, 52533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. First described as a mouse-specific duplication of the MARK kinase family, and named MarkmE1
    Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sperm motility kinase X
Names
MarkmE1
NP_941057.1
XP_006499881.1
XP_006499883.1
XP_036018235.1
XP_036018236.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198655.2 → NP_941057.1  sperm motility kinase X

    See identical proteins and their annotated locations for NP_941057.1

    Status: PROVISIONAL

    Source sequence(s)
    AL928719
    Consensus CDS
    CCDS38271.1
    UniProtKB/Swiss-Prot
    Q8C0X8
    Related
    ENSMUSP00000079030.3, ENSMUST00000080132.3
    Conserved Domains (2) summary
    cd14337
    Location:290 → 328
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:23 → 270
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    151302301..151318188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162342.1 → XP_036018235.1  sperm motility kinase X isoform X1

    UniProtKB/Swiss-Prot
    Q8C0X8
    Conserved Domains (2) summary
    cd14337
    Location:290 → 328
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:23 → 270
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

  2. XM_036162343.1 → XP_036018236.1  sperm motility kinase X isoform X2

    Conserved Domains (2) summary
    cd14337
    Location:290 → 328
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:23 → 270
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

  3. XM_006499820.2 → XP_006499883.1  sperm motility kinase X isoform X1

    See identical proteins and their annotated locations for XP_006499883.1

    UniProtKB/Swiss-Prot
    Q8C0X8
    Conserved Domains (2) summary
    cd14337
    Location:290 → 328
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:23 → 270
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases

  4. XM_006499818.2 → XP_006499881.1  sperm motility kinase X isoform X1

    See identical proteins and their annotated locations for XP_006499881.1

    UniProtKB/Swiss-Prot
    Q8C0X8
    Conserved Domains (2) summary
    cd14337
    Location:290 → 328
    UBA_MARK_Par1; UBA domain found in microtubule-associated protein (MAP)/microtubule affinity-regulating kinase (MARK)/ partitioning-defective 1 (Par-1) and similar proteins
    cd14003
    Location:23 → 270
    STKc_AMPK-like; Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0X8.1 GenPept UniProtKB/Swiss-Prot:Q8C0X8

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