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Ighg Immunoglobulin heavy chain (gamma polypeptide) [ Mus musculus (house mouse) ]

Gene ID: 380794, updated on 25-Jan-2024

Summary

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Official Symbol
Ighgprovided by MGI
Official Full Name
Immunoglobulin heavy chain (gamma polypeptide)provided by MGI
Primary source
MGI:MGI:2144967
See related
AllianceGenome:MGI:2144967
Gene type
protein coding
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGHG2A
Summary
Enables immunoglobulin receptor binding activity. Acts upstream of or within response to bacterium. Predicted to be part of immunoglobulin complex, circulating. Predicted to be active in external side of plasma membrane. Used to study type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
not in current annotation release
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Genomic context

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Location:
12 F2; 12 62.1 cM

Bibliography

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Related articles in PubMed

  1. Sequence analysis of anti-AChR antibodies in experimental autoimmune myasthenia gravis. Graus Y, et al. J Immunol, 1995 Jun 15. PMID 7539019
  2. O-glycosylation in hinge region of mouse immunoglobulin G2b. Kim H, et al. J Biol Chem, 1994 Apr 22. PMID 7512967
  3. Structure of the constant and 3' untranslated regions of the murine gamma 2b heavy chain messenger RNA. Tucker PW, et al. Science, 1979 Dec 14. PMID 117548
  4. Mouse immunoglobulin allotypes: post-duplication divergence of gamma 2a and gamma 2b chain genes. Ollo R, et al. Nature, 1982 Apr 22. PMID 6803173
  5. Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA. Sikorav JL, et al. Nucleic Acids Res, 1980 Jul 25. PMID 6777755, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Clone Names

  • MGC102604, MGC102659

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Fc-gamma receptor I complex binding ISO
Inferred from Sequence Orthology
more info
  
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables immunoglobulin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of IgG immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
part_of immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Names
Immunoglobulin heavy chain (gamma polypeptide)

NCBI Reference Sequences (RefSeq)

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Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_212451.1: Suppressed sequence

    Description
    NM_212451.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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