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Atf-2 Activating transcription factor-2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37978, updated on 10-May-2024

Summary

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Official Symbol
Atf-2provided by FlyBase
Official Full Name
Activating transcription factor-2provided by FlyBase
Primary source
FLYBASE:FBgn0265193
Locus tag
Dmel_CG44246
See related
AllianceGenome:FB:FBgn0265193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
atf-2; ATF-2; atf2; Atf2; ATF2; CG12850; CG30420; CG44246; dATF-2; dATF2; DM5; Dmel\CG44246; FBgn0050420
Old locus tag
Dmel_CG30420
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to heat; regulation of cellular biosynthetic process; and stress-activated MAPK cascade. Located in chromocenter; nucleus; and pericentric heterochromatin. Is expressed in organism. Orthologous to several human genes including ATF2 (activating transcription factor 2); ATF7 (activating transcription factor 7); and CREB5 (cAMP responsive element binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Atf-2 in Genome Data Viewer
Location:
60E4-60E4; 2-107 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24870108..24871509)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20757631..20759032)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44829 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potential Application of Drosophila melanogaster as a Model Organism in COVID-19-Related Research. Nainu F, et al. Front Pharmacol, 2020. PMID 33013425, Free PMC Article
  2. Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila. Kohyama-Koganeya A, et al. J Lipid Res, 2011 Jul. PMID 21550991, Free PMC Article
  3. Alternative models for transgenerational epigenetic inheritance: Molecular psychiatry beyond mice and man. Hime GR, et al. World J Psychiatry, 2021 Oct 19. PMID 34733638, Free PMC Article
  4. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells. Seong KH, et al. Commun Biol, 2020 May 4. PMID 32367035, Free PMC Article
  5. Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons. Shimizu H, et al. Mol Cell Biol, 2008 Oct. PMID 18694958, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
    Title: Paternal restraint stress affects offspring metabolism via ATF-2 dependent mechanisms in Drosophila melanogaster germ cells.
  2. This study reveals that Drosophila ATF-2 (dATF-2) is required for heterochromatin assembly, whereas the stress-induced phosphorylation of dATF-2, via Mekk1-p38, disrupts heterochromatin.
    Title: Inheritance of stress-induced, ATF-2-dependent epigenetic change.
  3. dATF-2 is activated by the locomotor while it increases sleep, suggesting a role for dATF-2 as a regulator to connect sleep with locomotion.
    Title: Drosophila ATF-2 regulates sleep and locomotor activity in pacemaker neurons.
  4. ATF-2 is critical for regulation of fat metabolism.
    Title: ATF-2 regulates fat metabolism in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mucosal immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromocenter IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
activating transcription factor-2
Names
Atf-2-PA
CG44246-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24870108..24871509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038884.2 → NP_001033973.1  activating transcription factor-2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2PE13, Q56H90
    Conserved Domains (1) summary
    pfam07989
    Location:300 → 336
    Cnn_1N; Centrosomin N-terminal motif 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2PE13 Q2PE13
Q56H90 Q56H90

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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