U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mAChR-A muscarinic Acetylcholine Receptor, A-type [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37892, updated on 26-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
mAChR-Aprovided by FlyBase
Official Full Name
muscarinic Acetylcholine Receptor, A-typeprovided by FlyBase
Primary source
FLYBASE:FBgn0000037
Locus tag
Dmel_CG4356
See related
AllianceGenome:FB:FBgn0000037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Acr60C; AcrC; CG4356; Dm-mAChR-A; Dm1; DM1; Dmel\CG4356; mAchR; mAChR; mAChR A; mAChR-1; mAChR-A1; mAcR; mAcR-60C; mAcR60C
Summary
Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; autoimmune disease of the nervous system (multiple); heroin dependence; lung disease (multiple); and prune belly syndrome. Orthologous to several human genes including CHRM1 (cholinergic receptor muscarinic 1); CHRM3 (cholinergic receptor muscarinic 3); and CHRM5 (cholinergic receptor muscarinic 5). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
60C7-60C7; 2-106 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24378630..24390294, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20266153..20277817, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene blistered Neighboring gene blistered anti-sense lncRNA Neighboring gene transfer RNA:Asparagine-GTT 1-9 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44813 Neighboring gene Sterile20-like kinase Neighboring gene Regulatory particle non-ATPase 8

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GPCR voltage dependence controls neuronal plasticity and behavior. Rozenfeld E, et al. Nat Commun, 2021 Dec 13. PMID 34903750, Free PMC Article
  2. Muscarinic Modulation of Antennal Lobe GABAergic Local Neurons Shapes Odor Coding and Behavior. Rozenfeld E, et al. Cell Rep, 2019 Dec 3. PMID 31801087, Free PMC Article
  3. Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart. Malloy CA, et al. J Comp Physiol B, 2016 Jan. PMID 26438517
  4. Insect muscarinic acetylcholine receptor: pharmacological and toxicological profiles of antagonists and agonists. Honda H, et al. J Agric Food Chem, 2007 Mar 21. PMID 17319687
  5. Spatiotemporal calcium signaling in a Drosophila melanogaster cell line stably expressing a Drosophila muscarinic acetylcholine receptor. Cordova D, et al. Invert Neurosci, 2003 Nov. PMID 12827518

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the Drosophila larval locomotor network.
    Title: Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in the Drosophila larval locomotor network.
  2. mAChR-A function in Kenyon cell dendrites is required for synaptic plasticity between Kenyon cells and their output neurons.
    Title: Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled acetylcholine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled acetylcholine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled amine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
muscarinic acetylcholine Receptor, A-type
Names
A-type mAChR
CG4356-PA
CG4356-PB
mAChR-A-PA
mAChR-A-PB
muscarinic acetylcholine receptor
muscarinic acetylcholine receptor 60C
muscarinic receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24378630..24390294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166668.2 → NP_726440.1  muscarinic acetylcholine Receptor, A-type, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726440.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P16395
    Related
    FBpp0072274
    Conserved Domains (2) summary
    pfam00001
    Location:121 → 314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:117 → 241
    7tm_4; Olfactory receptor

  2. NM_079120.3 → NP_523844.2  muscarinic acetylcholine Receptor, A-type, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523844.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G4LU59, M9NHK8, M9NKN3, P16395, Q1ECB8, Q8MLP2, Q9W180
    Related
    FBpp0072275
    Conserved Domains (2) summary
    pfam00001
    Location:121 → 314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:117 → 241
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16395.2 P16395

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous