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rdh1 retinol dehydrogenase 1 [ Danio rerio (zebrafish) ]

Gene ID: 378440, updated on 11-Apr-2024

Summary

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Official Symbol
rdh1provided by ZNC
Official Full Name
retinol dehydrogenase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030912-15
See related
Ensembl:ENSDARG00000017882 AllianceGenome:ZFIN:ZDB-GENE-030912-15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
RDHB
Summary
Enables NAD-retinol dehydrogenase activity. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; pancreas development; and retinoid metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in intestinal bulb and liver. Orthologous to human HSD17B6 (hydroxysteroid 17-beta dehydrogenase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 9
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (48674783..48700855, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (48977298..49003370, complement)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene zgc:172182 Neighboring gene low density lipoprotein receptor-related protein 2a Neighboring gene dehydrogenase/reductase (SDR family) member 9 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 11a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase. Mindnich R, et al. J Steroid Biochem Mol Biol, 2007 May. PMID 17467981
  2. Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity. Belyaeva OV, et al. Genomics, 2006 Dec. PMID 16860536
  3. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. Nadauld LD, et al. J Biol Chem, 2004 Dec 3. PMID 15358764
  4. Toxicity of triphenyltin on the development of retinal axons in zebrafish at low dose. Xiao Y, et al. Aquat Toxicol, 2017 Aug. PMID 28558289
  5. Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae. Xu T, et al. Environ Toxicol Pharmacol, 2013 Jan. PMID 23228703

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. zRDHA and zRDHB show strong expression within the gut of developing zebrafish embryos
    Title: Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation.
  2. A role for G143 in zebrafish 17beta-HSD 1 and M146 and M147 in the two zebrafish paralogs prRDH 1 and prRDH 2, respectively, in substrate specificity.
    Title: Functional aspects of 17beta-hydroxysteroid dehydrogenase 1 determined by comparison to a closely related retinol dehydrogenase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables all-trans-retinol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryonic heart tube development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic pectoral fin morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinal metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within retinol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 1; retinol dehydrogenase 2
NP_932335.1
XP_005167985.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198069.1 → NP_932335.1  retinol dehydrogenase 1

    See identical proteins and their annotated locations for NP_932335.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046089
    UniProtKB/TrEMBL
    Q7ZUX4
    Related
    ENSDARP00000003828.7, ENSDART00000026210.9
    Conserved Domains (2) summary
    pfam00106
    Location:40 → 224
    adh_short; short chain dehydrogenase
    cl21454
    Location:40 → 316
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    48674783..48700855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005167928.3 → XP_005167985.1  retinol dehydrogenase 2 isoform X1

    UniProtKB/TrEMBL
    A0A286Y8B5, A0A8M2BFD1
    Related
    ENSDARP00000143394.1, ENSDART00000178332.2
    Conserved Domains (2) summary
    PRK06182
    Location:40 → 319
    PRK06182; short chain dehydrogenase; Validated
    cl21454
    Location:40 → 316
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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