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ACTN1 actinin, alpha 1 [ Gallus gallus (chicken) ]

Gene ID: 373918, updated on 3-Apr-2024

Summary

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Official Symbol
ACTN1provided by CGNC
Official Full Name
actinin, alpha 1provided by CGNC
Primary source
CGNC:48956
See related
Ensembl:ENSGALG00010020389
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
24
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (27732414..27814071)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (27692305..27773943)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene exonuclease 3'-5' domain containing 2 Neighboring gene DDB1 and CUL4 associated factor 5 Neighboring gene uncharacterized LOC121110868 Neighboring gene uncharacterized LOC112532527 Neighboring gene serine/arginine-rich splicing factor 5a Neighboring gene microRNA 1617

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a cDNA encoding a chick alpha-actinin. Baron MD, et al. J Biol Chem, 1987 Feb 25. PMID 3818609
  2. The sequence of chick alpha-actinin reveals homologies to spectrin and calmodulin. Baron MD, et al. J Biol Chem, 1987 Dec 25. PMID 2826427
  3. Mutually exclusive splicing of calcium-binding domain exons in chick alpha-actinin. Waites GT, et al. J Biol Chem, 1992 Mar 25. PMID 1556133
  4. Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes. Zhang ZQ, et al. Exp Cell Res, 2009 Mar 10. PMID 19166831
  5. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. Pomiès P, et al. J Cell Biol, 1997 Oct 6. PMID 9314536, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A critical region of s-alpha-actinin that affects the width and integrity of the Z-line. This region is at least involved in the interaction with vinculin.
    Title: Sarcomeric-alpha-actinin defective in vinculin-binding causes Z-line expansion and nemaline-like body formation in cultured chick myotubes.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-1
Names
F-actin cross-linking protein
non-muscle alpha-actinin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204127.2 → NP_989458.2  alpha-actinin-1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000214
    UniProtKB/TrEMBL
    A0A8V0ZKK8
    Related
    ENSGALP00010029143.1, ENSGALT00010049295.1
    Conserved Domains (6) summary
    COG5126
    Location:744 → 888
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:396 → 623
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:635 → 734
    Spectrin; Spectrin repeat
    pfam08726
    Location:818 → 884
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:29 → 133
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:137 → 251
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    27732414..27814071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015287257.4 → XP_015142743.1  alpha-actinin-1 isoform X5

    UniProtKB/TrEMBL
    A0A1D5P9P3, A0A8V0ZKK8
    Related
    ENSGALP00010029158.1, ENSGALT00010049315.1
    Conserved Domains (6) summary
    cd00051
    Location:751 → 840
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:396 → 623
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:635 → 734
    Spectrin; Spectrin repeat
    pfam08726
    Location:845 → 911
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:29 → 133
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:137 → 251
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_015287258.4 → XP_015142744.1  alpha-actinin-1 isoform X1

    UniProtKB/Swiss-Prot
    P05094, Q99001
    UniProtKB/TrEMBL
    A0A8V0ZKK8
    Related
    ENSGALP00010029162.1, ENSGALT00010049325.1
    Conserved Domains (6) summary
    cd00051
    Location:751 → 818
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd00176
    Location:396 → 623
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam00435
    Location:635 → 734
    Spectrin; Spectrin repeat
    pfam08726
    Location:823 → 889
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:29 → 133
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:137 → 251
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_046941334.1 → XP_046797290.1  alpha-actinin-1 isoform X2

    Related
    ENSGALP00010029166.1, ENSGALT00010049333.1

  4. XM_046941335.1 → XP_046797291.1  alpha-actinin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZD41
    Related
    ENSGALP00010029139.1, ENSGALT00010049290.1

  5. XM_046941336.1 → XP_046797292.1  alpha-actinin-1 isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    27692305..27773943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917605.1 → XP_046773561.1  alpha-actinin-1 isoform X5

    UniProtKB/TrEMBL
    A0A1D5P9P3

  2. XM_046917601.1 → XP_046773557.1  alpha-actinin-1 isoform X1

    UniProtKB/Swiss-Prot
    P05094, Q99001

  3. XM_046917602.1 → XP_046773558.1  alpha-actinin-1 isoform X2

  4. XM_046917603.1 → XP_046773559.1  alpha-actinin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZD41

  5. XM_046917604.1 → XP_046773560.1  alpha-actinin-1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05094.3 GenPept UniProtKB/Swiss-Prot:P05094

Gene LinkOut

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