grk7b G protein-coupled receptor kinase 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: grk7bprovided by ZNC
Official Full Name: G protein-coupled receptor kinase 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030904-3
See related: Ensembl:ENSDARG00000055534 AllianceGenome:ZFIN:ZDB-GENE-030904-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: grk7; gprk7
Summary: Enables rhodopsin kinase activity. Predicted to be involved in protein phosphorylation and regulation of signal transduction. Predicted to act upstream of or within protein phosphopantetheinylation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in brain; epiphysis; eye; and retinal photoreceptor layer. Orthologous to human GRK7 (G protein-coupled receptor kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (41740752..41754007, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (41750560..41763815, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP.
Title: Grk7 but not Grk1 undergoes cAMP-dependent phosphorylation in zebrafish cone photoreceptors and mediates cone photoresponse recovery to elevated cAMP.
The function of a grk7 is essential for cone vision in the zebrafish retina and argue that pigment bleaching and spontaneous decay alone are not sufficient for light adaptation and rapid cone response inactivation.
Title: Knockdown of cone-specific kinase GRK7 in larval zebrafish leads to impaired cone response recovery and delayed dark adaptation.
In situ hybridization and immunohistochemical studies localizes both GRK1B and GRK7-1 in the cone outer segments.
Title: GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables rhodopsin kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rhodopsin kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables rhodopsin kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rhodopsin kinase grk7-b

Names: G protein-coupled receptor kinase 7-2; grk7-2; rhodopsin kinase 2

NP_001028262.1

EC 2.7.11.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033090.1 → NP_001028262.1 rhodopsin kinase grk7-b

See identical proteins and their annotated locations for NP_001028262.1

Status: PROVISIONAL

Source sequence(s)

AY900005

UniProtKB/Swiss-Prot

Q1XHL7

UniProtKB/TrEMBL

Q49HM8

Related

ENSDARP00000072364.5, ENSDART00000077898.6

Conserved Domains (2) summary

cl02565
Location:37 → 177

RGS; Regulator of G protein signaling (RGS) domain superfamily

cl21453
Location:184 → 466

PKc_like; Protein Kinases, catalytic domain