plk4 polo-like kinase 4 (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plk4provided by ZNC
Official Full Name: polo-like kinase 4 (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030619-14
See related: Ensembl:ENSDARG00000004576 AllianceGenome:ZFIN:ZDB-GENE-030619-14
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: stk18; wu:fi33g07
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within centriole assembly; cilium assembly; and developmental growth. Predicted to be located in centriole; deuterosome; and nucleolus. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in brain; eye; nervous system; and pronephros. Used to study ciliopathy. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Orthologous to human PLK4 (polo like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (43410747..43428397, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (43420213..43437859, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo.
Title: PLK1- and PLK4-Mediated Asymmetric Mitotic Centrosome Size and Positioning in the Early Zebrafish Embryo.
results provide the first steps in defining a new role for plk4 in organogenesis and implies a role in planar cell polarity, segmentation, and in recently described PLK4 mutations in human
Title: Developmental role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within centriole assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK4

Names: PLK-4; serine/threonine kinase 18; serine/threonine-protein kinase Sak

NP_001112364.1

EC 2.7.11.21

XP_005158928.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001118892.1 → NP_001112364.1 serine/threonine-protein kinase PLK4

Status: PROVISIONAL

Source sequence(s)

CR405694

UniProtKB/Swiss-Prot

Q7ZVS3

UniProtKB/TrEMBL

A0A8M1NG63, F1RB74

Related

ENSDARP00000043865.6, ENSDART00000043866.7

Conserved Domains (5) summary

smart00220
Location:12 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13114
Location:566 → 676

POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13115
Location:677 → 786

POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13116
Location:856 → 935

POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd14186
Location:10 → 265

STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

43410747..43428397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005158871.4 → XP_005158928.1 serine/threonine-protein kinase PLK4 isoform X1

UniProtKB/Swiss-Prot

Q7ZVS3

UniProtKB/TrEMBL

A0A8M2B5U8

Conserved Domains (5) summary

smart00220
Location:34 → 287

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13114
Location:588 → 698

POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13115
Location:699 → 808

POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13116
Location:878 → 957

POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd14186
Location:32 → 287

STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4