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Marchf3 membrane associated ring-CH-type finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 364878, updated on 11-Apr-2024

Summary

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Official Symbol
Marchf3provided by RGD
Official Full Name
membrane associated ring-CH-type finger 3provided by RGD
Primary source
RGD:1359308
See related
Ensembl:ENSRNOG00000023013 AllianceGenome:RGD:1359308
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
March3
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in endosome and lysosome. Orthologous to human MARCHF3 (membrane associated ring-CH-type finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 50.6), Lung (RPKM 35.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (52435292..52587321, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (50237218..50389343, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (51844980..51998017, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483028 Neighboring gene uncharacterized LOC120098251 Neighboring gene lamin B1 Neighboring gene small ribosomal subunit protein uS3-like Neighboring gene uncharacterized LOC120098149 Neighboring gene similar to human chromosome 5 open reading frame 63 Neighboring gene mitochondrial ribosomal protein L30, pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MARCH-III Is a novel component of endosomes with properties similar to those of MARCH-II. Fukuda H, et al. J Biochem, 2006 Jan. PMID 16428329
  2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC94648

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase MARCHF3
Names
E3 ubiquitin-protein ligase MARCH3
MARCH-III
RING-type E3 ubiquitin transferase MARCH3
RING-type E3 ubiquitin transferase MARCHF3
membrane-associated RING finger protein 3
membrane-associated RING-CH protein III
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
NP_001007760.1
XP_006254811.1
XP_063133562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007759.1 → NP_001007760.1  E3 ubiquitin-protein ligase MARCHF3

    See identical proteins and their annotated locations for NP_001007760.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083738
    UniProtKB/Swiss-Prot
    Q33E96, Q5XIE5
    UniProtKB/TrEMBL
    A0A8L2QGG7
    Related
    ENSRNOP00000030051.4, ENSRNOT00000039177.5
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    52435292..52587321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254749.5 → XP_006254811.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

    See identical proteins and their annotated locations for XP_006254811.1

    UniProtKB/Swiss-Prot
    Q33E96, Q5XIE5
    UniProtKB/TrEMBL
    A0A8L2QGG7
    Related
    ENSRNOP00000071176.1
    Conserved Domains (1) summary
    cd16699
    Location:70 → 120
    RING_CH-C4HC3_MARCH2_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH2, MARCH3, and similar proteins

  2. XM_063277492.1 → XP_063133562.1  E3 ubiquitin-protein ligase MARCHF3 isoform X1

    UniProtKB/Swiss-Prot
    Q33E96, Q5XIE5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIE5.1 GenPept UniProtKB/Swiss-Prot:Q5XIE5

Gene LinkOut

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