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Ankrd54 ankyrin repeat domain 54 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362957, updated on 13-Apr-2024

Summary

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Official Symbol
Ankrd54provided by RGD
Official Full Name
ankyrin repeat domain 54provided by RGD
Primary source
RGD:1309552
See related
Ensembl:ENSRNOG00000010821 AllianceGenome:RGD:1309552
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309552
Summary
Predicted to enable protein kinase regulator activity. Predicted to be involved in positive regulation of erythrocyte differentiation; regulation of intracellular signal transduction; and regulation of protein kinase activity. Predicted to act upstream of or within nucleocytoplasmic transport. Predicted to be located in midbody. Predicted to be active in cytoplasm and nucleus. Orthologous to human ANKRD54 (ankyrin repeat domain 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 111.5), Thymus (RPKM 38.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112495396..112508186, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110614942..110627739, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120282423..120295647, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase Neighboring gene galanin receptor 3 Neighboring gene transfer RNA valine (anticodon AAC) 17 Neighboring gene eukaryotic translation initiation factor 3, subunit L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Samuels AL, et al. Blood, 2009 Apr 16. PMID 19064729
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nucleocytoplasmic transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025285.2 → NP_001020456.1  ankyrin repeat domain-containing protein 54

    See identical proteins and their annotated locations for NP_001020456.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    Q566C8
    UniProtKB/TrEMBL
    A0A8I6A3E9, A6HSP4
    Related
    ENSRNOP00000086964.1, ENSRNOT00000098861.1
    Conserved Domains (3) summary
    cd00204
    Location:117 → 231
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:117 → 205
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:141 → 172
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112495396..112508186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242012.5 → XP_006242074.1  ankyrin repeat domain-containing protein 54 isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHI6, A0A8I6A3E9
    Related
    ENSRNOP00000014413.7
    Conserved Domains (3) summary
    cd00204
    Location:117 → 231
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:117 → 205
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:141 → 172
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q566C8.1 GenPept UniProtKB/Swiss-Prot:Q566C8

Gene LinkOut

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