Ankle1 ankyrin repeat and LEM domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ankle1provided by RGD
Official Full Name: ankyrin repeat and LEM domain containing 1provided by RGD
Primary source: RGD:1308184
See related: Ensembl:ENSRNOG00000017156 AllianceGenome:RGD:1308184
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ankrd41; RGD1308184
Summary: Predicted to enable endonuclease activity. Predicted to be involved in several processes, including negative regulation of mitotic recombination; protein export from nucleus; and regulation of hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with nucleus. Orthologous to human ANKLE1 (ankyrin repeat and LEM domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 39.0), Spleen (RPKM 31.7) and 7 other tissues See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (18109865..18116999)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (18076413..18082356)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (19799943..19826057)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
NOT involved_in DNA repair	ISO Inferred from Sequence Orthology more info
NOT involved_in determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mitotic recombination	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myeloid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in resolution of meiotic recombination intermediates	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_039095020.2 → XP_038950948.1 ankyrin repeat and LEM domain-containing protein 1 isoform X4

Conserved Domains (2) summary

PTZ00322
Location:60 → 160

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

sd00045
Location:75 → 106

ANK; ANK repeat [structural motif]
XM_063275923.1 → XP_063131993.1 ankyrin repeat and LEM domain-containing protein 1 isoform X1
XM_063275924.1 → XP_063131994.1 ankyrin repeat and LEM domain-containing protein 1 isoform X2
XM_039095019.2 → XP_038950947.1 ankyrin repeat and LEM domain-containing protein 1 isoform X3

Conserved Domains (3) summary

PTZ00322
Location:60 → 160

PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional

sd00045
Location:75 → 106

ANK; ANK repeat [structural motif]

cl02649
Location:266 → 303

LEM; LEM (Lap2/Emerin/Man1) domain found in emerin, lamina-associated polypeptide 2 (LAP2), inner nuclear membrane protein Man1 and similar proteins