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Prune2 prune homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 353211, updated on 21-Apr-2024

Summary

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Official Symbol
Prune2provided by MGI
Official Full Name
prune homolog 2provided by MGI
Primary source
MGI:MGI:1925004
See related
Ensembl:ENSMUSG00000039126 AllianceGenome:MGI:1925004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmcc1; Olfaxin; mKIAA0367; 6330414G02Rik; A230083H22Rik; A330102H22Rik
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human PRUNE2 (prune homolog 2 with BCH domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 10.0), frontal lobe adult (RPKM 5.5) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 B; 19 12.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16933033..17201322)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16955668..17223963)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene forkhead box B2 Neighboring gene predicted gene, 32341 Neighboring gene STARR-seq mESC enhancer starr_45670 Neighboring gene STARR-seq mESC enhancer starr_45671 Neighboring gene STARR-seq mESC enhancer starr_45673 Neighboring gene STARR-seq mESC enhancer starr_45676 Neighboring gene STARR-positive B cell enhancer ABC_E4271 Neighboring gene STARR-seq mESC enhancer starr_45678 Neighboring gene STARR-seq mESC enhancer starr_45679 Neighboring gene glucosaminyl (N-acetyl) transferase 1, core 2 Neighboring gene STARR-seq mESC enhancer starr_45680 Neighboring gene STARR-positive B cell enhancer ABC_E3246 Neighboring gene riboflavin kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Odor preference and olfactory memory are impaired in Olfaxin-deficient mice. Islam S, et al. Brain Res, 2018 Jun 1. PMID 29571668
  2. The expression and localization of Prune2 mRNA in the central nervous system. Li S, et al. Neurosci Lett, 2011 Oct 10. PMID 21893162
  3. Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system. Li S, et al. Brain Res, 2012 Dec 7. PMID 23059019
  4. Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions. Arama J, et al. PLoS One, 2012. PMID 22523599, Free PMC Article
  5. Increased expression of proapoptotic BMCC1, a novel gene with the BNIP2 and Cdc42GAP homology (BCH) domain, is associated with favorable prognosis in human neuroblastomas. Machida T, et al. Oncogene, 2006 Mar 23. PMID 16288218

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that odor preference and olfactory memory are impaired in Prune 2deficient mice. Knockout of Prune2 leads to a decrease in the Prune2 protein isoform Olfaxin. Levels of Olfaxin mRNA were decreased.
    Title: Odor preference and olfactory memory are impaired in Olfaxin-deficient mice.
  2. kidney-type glutaminase (KGA) as a novel partner of Bmcc1s
    Title: Bmcc1s interacts with the phosphate-activated glutaminase in the brain.
  3. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex.
    Title: Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
  4. This study identifies Bmcc1s as a new MAP6 interacting protein able to modulate MAP6-induced microtubule cold stability.
    Title: Bmcc1s, a novel brain-isoform of Bmcc1, affects cell morphology by regulating MAP6/STOP functions.
  5. Prune2 mRNA is predominantly expressed in the neurons of the cranial nerve motor nuclei and the motor neurons of the spinal cord
    Title: The expression and localization of Prune2 mRNA in the central nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0367

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
protein prune homolog 2
Names
BNIP2 motif-containing molecule at the C-terminal region 1
neuronal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181348.4 → NP_851993.3  protein prune homolog 2

    See identical proteins and their annotated locations for NP_851993.3

    Status: VALIDATED

    Source sequence(s)
    AC126674, AC147026, AK039241, BC094224
    Consensus CDS
    CCDS50400.1
    UniProtKB/Swiss-Prot
    Q501M3, Q52KR3, Q6A079, Q8BW65, Q8BYM6, Q9D217
    Related
    ENSMUSP00000084977.5, ENSMUST00000087689.5
    Conserved Domains (4) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:220 → 313
    DHHA2; DHHA2 domain
    pfam12496
    Location:2782 → 2899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2901 → 3022
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    16933033..17201322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527145.3 → XP_006527208.1  protein prune homolog 2 isoform X2

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2891
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2903 → 3040
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. XM_006527149.4 → XP_006527212.1  protein prune homolog 2 isoform X10

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  3. XM_006527147.4 → XP_006527210.1  protein prune homolog 2 isoform X5

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  4. XM_006527152.4 → XP_006527215.1  protein prune homolog 2 isoform X14

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. XM_006527151.4 → XP_006527214.1  protein prune homolog 2 isoform X13

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  6. XM_036161615.1 → XP_036017508.1  protein prune homolog 2 isoform X11

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  7. XM_006527153.4 → XP_006527216.1  protein prune homolog 2 isoform X16

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  8. XM_017318226.3 → XP_017173715.1  protein prune homolog 2 isoform X3

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2898
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2900 → 3037
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  9. XM_017318229.3 → XP_017173718.1  protein prune homolog 2 isoform X9

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2898
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2900 → 3037
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  10. XM_036161614.1 → XP_036017507.1  protein prune homolog 2 isoform X6

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  11. XM_036161616.1 → XP_036017509.1  protein prune homolog 2 isoform X12

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  12. XM_006527144.4 → XP_006527207.1  protein prune homolog 2 isoform X1

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  13. XM_006527146.3 → XP_006527209.1  protein prune homolog 2 isoform X4

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2904 → 3041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  14. XM_017318228.3 → XP_017173717.1  protein prune homolog 2 isoform X8

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2901 → 3038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  15. XM_017318230.3 → XP_017173719.1  protein prune homolog 2 isoform X15

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2901 → 3038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  16. XM_017318227.3 → XP_017173716.1  protein prune homolog 2 isoform X7

    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2901 → 3038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  17. XM_006527154.4 → XP_006527217.1  protein prune homolog 2 isoform X17

    UniProtKB/Swiss-Prot
    Q52KR3
    Conserved Domains (3) summary
    COG1227
    Location:24 → 284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:2782 → 2899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:2901 → 3032
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

  1. XR_004940154.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q52KR3.2 GenPept UniProtKB/Swiss-Prot:Q52KR3

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