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ZNF429 zinc finger protein 429 [ Homo sapiens (human) ]

Gene ID: 353088, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF429provided by HGNC
Official Full Name
zinc finger protein 429provided by HGNC
Primary source
HGNC:HGNC:20817
See related
Ensembl:ENSG00000197013 AllianceGenome:HGNC:20817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 1.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21505602..21540668)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21644168..21679216)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21688404..21723470)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372321 Neighboring gene MPRA-validated peak3411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21643213-21643712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21646023-21646921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21657297-21657950 Neighboring gene long intergenic non-protein coding RNA 664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688185-21688787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688788-21689389 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21694415-21695021 Neighboring gene BCL2 interacting protein 3 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21734180-21734961 Neighboring gene uncharacterized LOC124904670 Neighboring gene uncharacterized LOC101929007 Neighboring gene uncharacterized LOC105372323

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study of acute post-surgical pain in humans. Kim H, et al. Pharmacogenomics, 2009 Feb. PMID 19207018, Free PMC Article
  2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of acute post-surgical pain in humans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 429

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001415.4 → NP_001001415.2  zinc finger protein 429 isoform a

    See identical proteins and their annotated locations for NP_001001415.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010615, BM981242, DA533537
    Consensus CDS
    CCDS42537.1
    UniProtKB/Swiss-Prot
    A6NLV7, Q86V71, Q9BZE6
    Related
    ENSP00000351280.3, ENST00000358491.9
    Conserved Domains (5) summary
    smart00349
    Location:4 → 63
    KRAB; krueppel associated box
    COG5048
    Location:229 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427 → 447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:467 → 492
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001346912.2 → NP_001333841.1  zinc finger protein 429 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC010615

  3. NM_001346913.2 → NP_001333842.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC010615

  4. NM_001346914.2 → NP_001333843.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AC010615

  5. NM_001346915.2 → NP_001333844.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AC010615

  6. NM_001346916.2 → NP_001333845.1  zinc finger protein 429 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC010615

RNA

  1. NR_144522.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715

  2. NR_144523.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715

  3. NR_144524.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715

  4. NR_144525.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615
    Related
    ENST00000598747.1

  5. NR_144526.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615
    Related
    ENST00000597556.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    21505602..21540668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438765.1 → XP_047294721.1  zinc finger protein 429 isoform X1

  2. XM_017026748.3 → XP_016882237.1  zinc finger protein 429 isoform X1

  3. XM_017026752.2 → XP_016882241.1  zinc finger protein 429 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21644168..21679216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320855.1 → XP_054176830.1  zinc finger protein 429 isoform X1

  2. XM_054320857.1 → XP_054176832.1  zinc finger protein 429 isoform X1

  3. XM_054320856.1 → XP_054176831.1  zinc finger protein 429 isoform X1

  4. XM_054320858.1 → XP_054176833.1  zinc finger protein 429 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86V71.2 GenPept UniProtKB/Swiss-Prot:Q86V71

Gene LinkOut

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