U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GCS2beta Glucosidase 2 beta subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35056, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GCS2betaprovided by FlyBase
Official Full Name
Glucosidase 2 beta subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0032643
Locus tag
Dmel_CG6453
See related
AllianceGenome:FB:FBgn0032643
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6453; Dmel\CG6453; Q9VJD1_DROME
Summary
Predicted to be involved in N-glycan processing. Located in endomembrane system. Is expressed in adult head; adult heart; embryonic proventriculus; and organism. Human ortholog(s) of this gene implicated in liver disease and polycystic liver disease. Orthologous to human PRKCSH (protein kinase C substrate 80K-H). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GCS2beta in Genome Data Viewer
Location:
36C10-36C10; 2-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17481988..17484307, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17481988..17484307, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene cassowary Neighboring gene four way stop Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. Steele LD, et al. PLoS One, 2015. PMID 25826265, Free PMC Article
  2. Mutations in four glycosyl hydrolases reveal a highly coordinated pathway for rhodopsin biosynthesis and N-glycan trimming in Drosophila melanogaster. Rosenbaum EE, et al. PLoS Genet, 2014 May. PMID 24785692, Free PMC Article
  3. Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome. Herranz R, et al. Mol Ecol, 2010 Oct. PMID 20819157
  4. Quantitative Proteomic and Metabolomic Profiling Reveals Altered Mitochondrial Metabolism and Folate Biosynthesis Pathways in the Aging Drosophila Eye. Hall H, et al. Mol Cell Proteomics, 2021. PMID 34332122, Free PMC Article
  5. How Genetics Has Helped Piece Together the MAPK Signaling Pathway. Ashton-Beaucage D, et al. Methods Mol Biol, 2017. PMID 27924555

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
part_of glucosidase II complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glucosidase 2 beta subunit
Names
CG6453-PA
CG6453-PB
GCS2beta-PA
GCS2beta-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    17481988..17484307 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136000.3 → NP_609844.1  glucosidase 2 beta subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJD1
    Related
    FBpp0080551
    Conserved Domains (3) summary
    pfam12999
    Location:26 → 193
    PRKCSH-like; Glucosidase II beta subunit-like
    cd00112
    Location:85 → 120
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl06793
    Location:398 → 547
    PRKCSH; Glucosidase II beta subunit-like protein

  2. NM_001259134.2 → NP_001246063.1  glucosidase 2 beta subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246063.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJD1
    Conserved Domains (3) summary
    pfam12999
    Location:26 → 193
    PRKCSH-like; Glucosidase II beta subunit-like
    cd00112
    Location:85 → 120
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl06793
    Location:398 → 547
    PRKCSH; Glucosidase II beta subunit-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJD1 Q9VJD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous