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ZNF391 zinc finger protein 391 [ Homo sapiens (human) ]

Gene ID: 346157, updated on 11-Apr-2024

Summary

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Official Symbol
ZNF391provided by HGNC
Official Full Name
zinc finger protein 391provided by HGNC
Primary source
HGNC:HGNC:18779
See related
Ensembl:ENSG00000124613 AllianceGenome:HGNC:18779
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ153G14.3
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.3), thyroid (RPKM 2.1) and 23 other tissues See more
Orthologs
all
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Genomic context

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Location:
6p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27374615..27403908)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27243773..27273038)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27342394..27371687)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17024 Neighboring gene tRNA-iMet (anticodon CAT) 1-5 Neighboring gene tRNA-Lys (anticodon TTT) 6-1 Neighboring gene zinc finger protein 204, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:27335298-27335798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:27335799-27336299 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:27340678-27340840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24282 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:27346083-27346611 Neighboring gene zinc finger protein 184 Neighboring gene multiple coagulation factor deficiency 2 pseudogene 1 Neighboring gene MPRA-validated peak5742 silencer Neighboring gene MPRA-validated peak5743 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24286 Neighboring gene uncharacterized LOC105375001

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach. Ren H, et al. Schizophr Bull, 2021 Aug 21. PMID 33822213, Free PMC Article
  2. Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins. Review article. Fuchs O, et al. Sb Lek, 2003. PMID 14577126
  3. Singlet oxygen-induced signaling effects in mammalian cells. Klotz LO, et al. Photochem Photobiol Sci, 2003 Feb. PMID 12664966
  4. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. Brayer KJ, et al. Cell Biochem Biophys, 2008. PMID 18253864
  5. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.
    Title: Spatial Expression Pattern of ZNF391 Gene in the Brains of Patients With Schizophrenia, Bipolar Disorders or Major Depressive Disorder Identifies New Cross-Disorder Biotypes: A Trans-Diagnostic, Top-Down Approach.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 391

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076781.3 → NP_001070249.1  zinc finger protein 391

    See identical proteins and their annotated locations for NP_001070249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AK294965, AL031118, BC035154, BM906507, BX400006, CN294872, DB297905
    Consensus CDS
    CCDS43429.1
    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Related
    ENSP00000244576.4, ENST00000244576.9
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001322288.2 → NP_001309217.1  zinc finger protein 391

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AK294965, AL031118, BC035154, BG722372, BM906507, BX400006, CN294872, DB060105, DB297905
    Consensus CDS
    CCDS43429.1
    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001322289.2 → NP_001309218.1  zinc finger protein 391

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AK294965, AL031118, BC035154, BM906507, BX282552, BX400006, CN294872, DA758693, DB297905
    Consensus CDS
    CCDS43429.1
    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001322293.2 → NP_001309222.1  zinc finger protein 391

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AK294965, AL031118, BC035154, BM906507, BX400006, CN294872, DB297905
    Consensus CDS
    CCDS43429.1
    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    27374615..27403908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715086.3 → XP_006715149.1  zinc finger protein 391 isoform X1

    See identical proteins and their annotated locations for XP_006715149.1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011514569.2 → XP_011512871.1  zinc finger protein 391 isoform X1

    See identical proteins and their annotated locations for XP_011512871.1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005249082.3 → XP_005249139.1  zinc finger protein 391 isoform X1

    See identical proteins and their annotated locations for XP_005249139.1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7
    Conserved Domains (4) summary
    COG5048
    Location:163 → 340
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:333 → 355
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:151 → 176
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    27243773..27273038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355338.1 → XP_054211313.1  zinc finger protein 391 isoform X1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7

  2. XM_054355336.1 → XP_054211311.1  zinc finger protein 391 isoform X1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7

  3. XM_054355335.1 → XP_054211310.1  zinc finger protein 391 isoform X1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7

  4. XM_054355337.1 → XP_054211312.1  zinc finger protein 391 isoform X1

    UniProtKB/Swiss-Prot
    B4DH77, Q9UJN7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013719.1: Suppressed sequence

    Description
    NM_001013719.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJN7.2 GenPept UniProtKB/Swiss-Prot:Q9UJN7

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