U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DUBR DPPA2 upstream binding RNA [ Homo sapiens (human) ]

Gene ID: 344595, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
DUBRprovided by HGNC
Official Full Name
DPPA2 upstream binding RNAprovided by HGNC
Primary source
HGNC:HGNC:48569
See related
Ensembl:ENSG00000243701 MIM:616619; AllianceGenome:HGNC:48569
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUM; LINC0883; LINC00883
Summary
Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of myoblast differentiation; and regulation of DNA methylation. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary (RPKM 6.4), testis (RPKM 4.8) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (107240692..107326964)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (109960376..110046666)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (106959539..107045811)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene PTPN11 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 882 Neighboring gene NANOG hESC enhancer GRCh37_chr3:106861597-106862136 Neighboring gene uncharacterized LOC124909404 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14585 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:107003277-107004086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:107004087-107004896 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:107027390-107028318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:107034942-107035442 Neighboring gene CS pseudogene 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:107085622-107086821 Neighboring gene coiled-coil domain containing 54

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Linc00883 affects colorectal cancer through miR-577/FKBP14 axis: a novel mechanism for regulating colorectal cancer cell proliferation, invasion, and migration. Bai Y, et al. Cell Cycle, 2022 Nov. PMID 35833665, Free PMC Article
  2. DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation. Nie W, et al. Acta Pharmacol Sin, 2022 Jan. PMID 33758355, Free PMC Article
  3. LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. Wang L, et al. Cell Res, 2015 Mar. PMID 25686699, Free PMC Article
  4. Role of non-coding RNAs in maintaining primary airway smooth muscle cells. Perry MM, et al. Respir Res, 2014 May 16. PMID 24886442, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Linc00883 affects colorectal cancer through miR-577/FKBP14 axis: a novel mechanism for regulating colorectal cancer cell proliferation, invasion, and migration.
    Title: Linc00883 affects colorectal cancer through miR-577/FKBP14 axis: a novel mechanism for regulating colorectal cancer cell proliferation, invasion, and migration.
  2. DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation.
    Title: DUBR suppresses migration and invasion of human lung adenocarcinoma cells via ZBTB11-mediated inhibition of oxidative phosphorylation.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Markers

Homology

Other Names

  • long intergenic non-protein coding RNA 883

Clone Names

  • FLJ31372

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028301.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC074043, BC039550, BU618315, DA339707
    Related
    ENST00000466734.6

  2. NR_028302.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses the same first exon as variant 1, but has a distinct 3' splice pattern.
    Source sequence(s)
    AC063944, AK309100
    Related
    ENST00000490441.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    107240692..107326964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    109960376..110046666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials