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Aasdh Aminoadipate-semialdehyde dehydrogenase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34175, updated on 26-Apr-2024

Summary

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Official Symbol
Aasdhprovided by FlyBase
Official Full Name
Aminoadipate-semialdehyde dehydrogenaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027780
Locus tag
Dmel_CG13401
See related
AllianceGenome:FB:FBgn0027780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13401; Dmel\CG13401; U26
Summary
Predicted to be involved in fatty acid metabolic process. Orthologous to human AASDH (aminoadipate-semialdehyde dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
29C5-29C5; 2-32 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8445861..8449576, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8445861..8449576, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene mutagen-sensitive 201 Neighboring gene uncharacterized protein Neighboring gene 1-Acylglycerol-3-phosphate O-acyltransferase 2 Neighboring gene piragua

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nutritional biochemistry: A new redox-cofactor vitamin for mammals. Kasahara T, et al. Nature, 2003 Apr 24. PMID 12712191
  2. GeneFizz: A web tool to compare genetic (coding/non-coding) and physical (helix/coil) segmentations of DNA sequences. Gene discovery and evolutionary perspectives. Yeramian E, et al. Nucleic Acids Res, 2003 Jul 1. PMID 12824434, Free PMC Article
  3. Clueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin. Cox RT, et al. Dis Model Mech, 2009 Sep-Oct. PMID 19638420, Free PMC Article
  4. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article
  5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. U26 is involved in the lysine degradation pathway
    Title: Nutritional biochemistry: A new redox-cofactor vitamin for mammals.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-alanyl amine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in amino acid activation for nonribosomal peptide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Aminoadipate-semialdehyde dehydrogenase
Names
Aasdh-PA
Aasdh-PC
Aasdh-PD
CG13401-PA
CG13401-PC
CG13401-PD
U26

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8445861..8449576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135386.5 → NP_609230.2  Aminoadipate-semialdehyde dehydrogenase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609230.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1RKX6, Q9U973, Q9VLL0
    UniProtKB/TrEMBL
    F0JAI7
    Related
    FBpp0088615
    Conserved Domains (4) summary
    TIGR01733
    Location:46 → 443
    AA-adenyl-dom; amino acid adenylation domain
    pfam13360
    Location:732 → 978
    PQQ_2; PQQ-like domain
    cl11493
    Location:728 → 1012
    PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
    cl17068
    Location:168 → 522
    AFD_class_I; Adenylate forming domain, Class I superfamily

  2. NM_001298825.1 → NP_001285754.1  Aminoadipate-semialdehyde dehydrogenase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J591
    Conserved Domains (1) summary
    cl17068
    Location:168 → 299
    AFD_class_I; Adenylate forming domain, Class I superfamily

  3. NM_205938.2 → NP_995660.2  Aminoadipate-semialdehyde dehydrogenase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995660.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1RKX6, Q9U973, Q9VLL0
    UniProtKB/TrEMBL
    F0JAI7
    Conserved Domains (4) summary
    TIGR01733
    Location:46 → 443
    AA-adenyl-dom; amino acid adenylation domain
    pfam13360
    Location:732 → 978
    PQQ_2; PQQ-like domain
    cl11493
    Location:728 → 1012
    PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
    cl17068
    Location:168 → 522
    AFD_class_I; Adenylate forming domain, Class I superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VLL0.3 Q9VLL0
X2J591 X2J591

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