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Myo1d myosin ID [ Mus musculus (house mouse) ]

Gene ID: 338367, updated on 21-Apr-2024

Summary

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Official Symbol
Myo1dprovided by MGI
Official Full Name
myosin IDprovided by MGI
Primary source
MGI:MGI:107728
See related
Ensembl:ENSMUSG00000035441 AllianceGenome:MGI:107728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D11Ertd9e; myosin-1d; 9930104H07Rik
Summary
Predicted to enable several functions, including actin filament binding activity; calcium-dependent protein binding activity; and calmodulin binding activity. Involved in cellular localization. Located in several cellular components, including brush border; myelin sheath; and neuronal cell body. Is expressed in alimentary system; foot; and sensory organ. Orthologous to human MYO1D (myosin ID). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 42.4), colon adult (RPKM 39.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 47.95 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (80372945..80670881, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (80482126..80780055, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30149 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 Neighboring gene RIKEN cDNA C030013C21 gene Neighboring gene STARR-positive B cell enhancer ABC_E1835 Neighboring gene STARR-positive B cell enhancer ABC_E9833 Neighboring gene cyclin dependent kinase 5, regulatory subunit 1 Neighboring gene predicted gene, 53690 Neighboring gene STARR-seq mESC enhancer starr_30150 Neighboring gene predicted gene, 31109 Neighboring gene predicted gene, 38907 Neighboring gene STARR-seq mESC enhancer starr_30152 Neighboring gene STARR-positive B cell enhancer mm9_chr11:80524920-80525220 Neighboring gene predicted gene, 31042 Neighboring gene predicted gene, 31228 Neighboring gene 39S ribosomal protein L27, mitochondrial pseudogene Neighboring gene transmembrane protein 98

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The class I myosin MYO1D binds to lipid and protects against colitis. McAlpine W, et al. Dis Model Mech, 2018 Sep 27. PMID 30279225, Free PMC Article
  2. Myosin Id localizes in dendritic spines through the tail homology 1 domain. Koshida R, et al. Exp Cell Res, 2018 Jun 1. PMID 29559226
  3. New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D. Ko YS, et al. Clin Transl Med, 2021 Aug. PMID 34459138, Free PMC Article
  4. Expression and localization of myosin-1d in the developing nervous system. Benesh AE, et al. Brain Res, 2012 Feb 27. PMID 22284616, Free PMC Article
  5. Proteomic analysis of the enterocyte brush border. McConnell RE, et al. Am J Physiol Gastrointest Liver Physiol, 2011 May. PMID 21330445, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D.
    Title: New strategy for suppressing the growth of lung cancer cells harboring mutations in the ATP-binding region of EGFR by targeting the molecular motor MYO1D.
  2. these findings reveal that myosin Id localizes in dendritic spines through the TH1 domain.
    Title: Myosin Id localizes in dendritic spines through the tail homology 1 domain.
  3. MYO1D is needed to maintain epithelial integrity and protect against dextran sodium sulfate-induced colitis.
    Title: The class I myosin MYO1D binds to lipid and protects against colitis.
  4. analysis of myosin-1d expression patterns in the peripheral and central nervous systems during postnatal development
    Title: Expression and localization of myosin-1d in the developing nervous system.
  5. Data suggest that Myo1d may be the primary compensating class I myosin in the Myo1a KO model; they also suggest that dynamics govern the localization and function of different yet closely related myosins that target common actin structures.
    Title: Differential localization and dynamics of class I myosins in the enterocyte microvillus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183676

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in axolemma ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
part_of myosin complex ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
unconventional myosin-Id
Names
myosin-Id

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177390.3 → NP_796364.2  unconventional myosin-Id

    See identical proteins and their annotated locations for NP_796364.2

    Status: VALIDATED

    Source sequence(s)
    AK049374, AK148112
    Consensus CDS
    CCDS36242.1
    UniProtKB/Swiss-Prot
    Q5SSK7, Q5SYD0, Q8BWY5
    UniProtKB/TrEMBL
    B2RWZ2
    Related
    ENSMUSP00000037819.8, ENSMUST00000041065.14
    Conserved Domains (3) summary
    smart00242
    Location:4 → 694
    MYSc; Myosin. Large ATPases
    cd01378
    Location:24 → 682
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:803 → 997
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    80372945..80670881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156783.1 → XP_036012676.1  unconventional myosin-Id isoform X1

    UniProtKB/TrEMBL
    B2RWZ2
    Conserved Domains (2) summary
    cd01378
    Location:36 → 686
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:807 → 1000
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  2. XM_011249085.3 → XP_011247387.1  unconventional myosin-Id isoform X5

    UniProtKB/TrEMBL
    Q3UG58
    Conserved Domains (2) summary
    cl22853
    Location:14 → 183
    Motor_domain; Myosin and Kinesin motor domain
    pfam06017
    Location:304 → 497
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  3. XM_006533585.2 → XP_006533648.1  unconventional myosin-Id isoform X3

    UniProtKB/TrEMBL
    B2RWZ2
    Related
    ENSMUSP00000066948.6, ENSMUST00000070997.6
    Conserved Domains (2) summary
    cd01378
    Location:24 → 682
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:803 → 906
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  4. XM_036156784.1 → XP_036012677.1  unconventional myosin-Id isoform X2

    UniProtKB/TrEMBL
    B2RWZ2
    Conserved Domains (2) summary
    cd01378
    Location:36 → 686
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:807 → 910
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

  5. XM_036156785.1 → XP_036012678.1  unconventional myosin-Id isoform X4

    Conserved Domains (1) summary
    cl22853
    Location:36 → 517
    Motor_domain; Myosin and Kinesin motor domain

RNA

  1. XR_003949464.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SYD0.1 GenPept UniProtKB/Swiss-Prot:Q5SYD0

Gene LinkOut

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