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etv5a ETS variant transcription factor 5a [ Danio rerio (zebrafish) ]

Gene ID: 337626, updated on 30-Mar-2024

Summary

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Official Symbol
etv5aprovided by ZNC
Official Full Name
ETS variant transcription factor 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9572
See related
Ensembl:ENSDARG00000069763 AllianceGenome:ZFIN:ZDB-GENE-030131-9572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
etv5; fj87h10; zgc:55647; id:ibd5133; wu:fj87h10
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hemangioblast cell differentiation; limb morphogenesis; and pronephric nephron tubule epithelial cell differentiation. Predicted to be active in nucleus. Is expressed in several structures, including mesoderm; nervous system; neural tube; pronephros; and tail bud. Orthologous to human ETV5 (ETS variant transcription factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See etv5a in Genome Data Viewer
Location:
chromosome: 9
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (22631787..22649027)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (22820918..22838158)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase beta-like Neighboring gene crystallin, gamma S3 Neighboring gene uncharacterized LOC108191375 Neighboring gene RNA binding motif protein 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Divergence in regulation of the PEA3 family of ETS transcription factors. Roussigné M, et al. Gene Expr Patterns, 2006 Oct. PMID 16516559
  2. Prostaglandin signaling regulates renal multiciliated cell specification and maturation. Marra AN, et al. Proc Natl Acad Sci U S A, 2019 Apr 23. PMID 30948642, Free PMC Article
  3. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. Mechaly AS, et al. Gen Comp Endocrinol, 2017 May 15. PMID 28041791
  4. Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish. Spiró Z, et al. Sci Rep, 2016 Jun 7. PMID 27273160, Free PMC Article
  5. Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development. Marra AN, et al. Dev Biol, 2016 Mar 15. PMID 26827902, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. etv5a and etv4 have roles in mediating epithelial cell fate during zebrafish kidney development
    Title: Epithelial cell fate in the nephron tubule is mediated by the ETS transcription factors etv5a and etv4 during zebrafish kidney development.
  2. Zebrafish etv5a is essential for the inhibition of ventral mesoderm cell proliferation and for the formation of the hemato-vascular lineage.
    Title: Etv5a regulates the proliferation of ventral mesoderm cells and the formation of hemato-vascular derivatives.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemangioblast cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within limb morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pronephric nephron tubule epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ETS translocation variant 5; ETS translocation variant 5a
Names
ets variant gene 5 (ets-related molecule)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126461.2 → NP_001119933.1  ETS translocation variant 5a isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX548053
    UniProtKB/TrEMBL
    A0A8M9PRX2, B0S6S7
    Related
    ENSDARP00000108566.2, ENSDART00000126015.4
    Conserved Domains (2) summary
    smart00413
    Location:376 → 462
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 375
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. NM_001328592.1 → NP_001315521.1  ETS translocation variant 5a isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX548053
    UniProtKB/TrEMBL
    A0A8M1P578, F1Q6X6
    Related
    ENSDARP00000092546.5, ENSDART00000101770.5
    Conserved Domains (2) summary
    smart00413
    Location:376 → 460
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:1 → 375
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    22631787..22649027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478613.1 → XP_021334288.1  ETS translocation variant 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q4H5
    Conserved Domains (2) summary
    smart00413
    Location:375 → 461
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 374
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  2. XM_021478614.1 → XP_021334289.1  ETS translocation variant 5 isoform X3

    UniProtKB/TrEMBL
    A0A8M9QAL5
    Conserved Domains (2) summary
    smart00413
    Location:375 → 459
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 374
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

  3. XM_021478612.1 → XP_021334287.1  ETS translocation variant 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PRX2, B0S6S7
    Related
    ENSDARP00000156093.1, ENSDART00000181822.1
    Conserved Domains (2) summary
    smart00413
    Location:376 → 462
    ETS; erythroblast transformation specific domain
    pfam04621
    Location:2 → 375
    ETS_PEA3_N; PEA3 subfamily ETS-domain transcription factor N terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394751.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    444360..461600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395279.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    168425..186316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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