pepd peptidase D [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pepdprovided by ZNC
Official Full Name: peptidase Dprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9444
See related: Ensembl:ENSDARG00000102249 AllianceGenome:ZFIN:ZDB-GENE-030131-9444
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb1000; fj78g11; wu:fj78g11
Summary: Predicted to enable manganese ion binding activity and metalloaminopeptidase activity. Acts upstream of or within endocrine pancreas development and pancreas regeneration. Is expressed in blood vessel; eye; neural crest; optic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (1291888..1414675, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (1640566..1745499, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables proline dipeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: xaa-Pro dipeptidase

NP_944594.1

EC 3.4.13.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198912.1 → NP_944594.1 xaa-Pro dipeptidase

See identical proteins and their annotated locations for NP_944594.1

Status: PROVISIONAL

Source sequence(s)

BC055252

UniProtKB/TrEMBL

Q7SXT5

Related

ENSDARP00000137800.2, ENSDART00000171881.2

Conserved Domains (3) summary

smart01011
Location:19 → 156

AMP_N; Aminopeptidase P, N-terminal domain

PRK13607
Location:47 → 467

PRK13607; proline dipeptidase; Provisional

cd01087
Location:193 → 468

Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...