setd3 SET domain containing 3, actin histidine methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: setd3provided by ZNC
Official Full Name: SET domain containing 3, actin histidine methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9137
See related: Ensembl:ENSDARG00000016513 AllianceGenome:ZFIN:ZDB-GENE-030131-9137
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb01d12; zgc:63842; wu:fb01d12
Summary: Enables histone methyltransferase activity (H3-K36 specific) and transcription coactivator activity. Involved in peptidyl-lysine methylation and positive regulation of transcription, DNA-templated. Predicted to be located in cytoplasm. Orthologous to human SETD3 (SET domain containing 3, actin histidine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (18031899..18070787)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (18012063..18050951)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of setd3 decreased cell viability and activated caspase-3, indicating possible roles in apoptotic cell death and cell cycle regulation.
Title: Characterization of a novel histone H3K36 methyltransferase setd3 in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb01d12.x1 (e-PCR)
- UniSTS:202653

fc47d04.y1 (e-PCR)
- UniSTS:193960

G47754 (e-PCR)
- UniSTS:108524

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables histone H3K36 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-histidine N-tele-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-L-histidine N-tele-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine monomethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine trimethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: actin-histidine N-methyltransferase

Names: SET domain-containing protein 3; histone-lysine N-methyltransferase setd3; protein-L-histidine N-tele-methyltransferase

NP_956348.1

EC 2.1.1.85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.