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nbr1a NBR1 autophagy cargo receptor a [ Danio rerio (zebrafish) ]

Gene ID: 337168, updated on 27-Mar-2024

Summary

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Official Symbol
nbr1aprovided by ZNC
Official Full Name
NBR1 autophagy cargo receptor aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9112
See related
Ensembl:ENSDARG00000077297 AllianceGenome:ZFIN:ZDB-GENE-030131-9112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
nbr1; fa99f08; wu:fa99f08
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in macroautophagy. Predicted to be active in phagophore assembly site. Orthologous to human NBR1 (NBR1 autophagy cargo receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (27213715..27229860)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (27122372..27138500)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100535964 Neighboring gene src kinase associated phosphoprotein 1 Neighboring gene proteasome activator subunit 3 Neighboring gene transmembrane protein 106A Neighboring gene uncharacterized LOC110440144 Neighboring gene ADP-ribosylation factor-like 4D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NBR1 autophagy cargo receptor a; next to BRCA1 gene 1 protein
Names
neighbor of brca1 gene 1
neighbor of brca1 gene 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305595.1 → NP_001292524.1  NBR1 autophagy cargo receptor a

    Status: VALIDATED

    Source sequence(s)
    BX001014
    UniProtKB/TrEMBL
    A0A8M1P6X5, E9QEG9
    Related
    ENSDARP00000121070.1, ENSDART00000133048.3
    Conserved Domains (4) summary
    cd14319
    Location:939 → 977
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    pfam16158
    Location:373 → 472
    N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
    cl00295
    Location:213 → 251
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02720
    Location:5 → 83
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    27213715..27229860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306753.3 → XP_009305028.1  next to BRCA1 gene 1 protein isoform X4

    UniProtKB/TrEMBL
    A0A8M3AYG6
    Conserved Domains (3) summary
    pfam16158
    Location:392 → 491
    N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
    cl00295
    Location:213 → 251
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02720
    Location:5 → 83
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  2. XM_021480033.1 → XP_021335708.1  next to BRCA1 gene 1 protein isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q884
    Conserved Domains (4) summary
    cd14319
    Location:967 → 1005
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cl00295
    Location:213 → 251
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02720
    Location:5 → 83
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    pfam16158
    Location:392 → 491
    N_BRCA1_IG; Ig-like domain from next to BRCA1 gene

  3. XM_001920581.6 → XP_001920616.3  next to BRCA1 gene 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A8M1QKG5
    Related
    ENSDART00000138141.2
    Conserved Domains (4) summary
    cd14319
    Location:958 → 996
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    pfam16158
    Location:392 → 491
    N_BRCA1_IG; Ig-like domain from next to BRCA1 gene
    cl00295
    Location:213 → 251
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02720
    Location:5 → 83
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...

  4. XM_021480034.1 → XP_021335709.1  next to BRCA1 gene 1 protein isoform X3

    UniProtKB/TrEMBL
    A0A8M9QE48
    Conserved Domains (4) summary
    cd14319
    Location:948 → 986
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cl00295
    Location:213 → 251
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cl02720
    Location:5 → 83
    PB1; The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1 ...
    pfam16158
    Location:373 → 472
    N_BRCA1_IG; Ig-like domain from next to BRCA1 gene

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394847.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    117849..133976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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