U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

adcyap1b adenylate cyclase activating polypeptide 1b [ Danio rerio (zebrafish) ]

Gene ID: 335625, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
adcyap1bprovided by ZNC
Official Full Name
adenylate cyclase activating polypeptide 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-89
See related
Ensembl:ENSDARG00000027740 AllianceGenome:ZFIN:ZDB-GENE-041010-89
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
PACAP2; acap1l; pacap1b; GHRH-LP2; zgc:92555; wu:fj30e08; zgc:101522
Summary
Predicted to enable neuropeptide hormone activity; peptide hormone receptor binding activity; and pituitary adenylate cyclase activating polypeptide activity. Acts upstream of or within brain development and camera-type eye development. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including basal plate midbrain region; male organism; nervous system; spleen; and trigeminal placode. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See adcyap1b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31297150..31302661, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31313932..31319443, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene elastin microfibril interfacer 2a Neighboring gene uncharacterized LOC101885430 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene clusterin-like 1 (retinal) Neighboring gene collectin sub-family member 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Distribution of pituitary adenylate cyclase-activating polypeptide 2 in zebrafish brain. Nakamachi T, et al. Peptides, 2018 May. PMID 29535004
  2. Differential regulation of kit ligand A (kitlga) expression in the zebrafish ovarian follicle cells--evidence for the existence of a cyclic adenosine 3', 5' monophosphate-mediated binary regulatory system during folliculogenesis. Yao K, et al. Mol Cell Endocrinol, 2015 Feb 15. PMID 25542847
  3. Cloning, regulation of messenger ribonucleic acid expression, and function of a new isoform of pituitary adenylate cyclase-activating polypeptide in the zebrafish ovary. Wang Y, et al. Endocrinology, 2003 Nov. PMID 12959988
  4. Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio). Castro A, et al. J Comp Neurol, 2009 Apr 20. PMID 19235874
  5. Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish. Nakamachi T, et al. Front Endocrinol (Lausanne), 2019. PMID 31031705, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish.
    Title: Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish.
  2. A nanomolar dose of PACAP-38 inhibits neutrophil migration towards damaged zebrafish hair cells undergoing chemically induced necrosis and consequent inflammation. CuSO4 exposure up-regulated the expression of IL-8, IL-1beta, IL-6 and ATF3, while after PACAP-38 co-treatment expression levels of these genes were significantly decreased.
    Title: Pituitary adenylate cyclase-activating polypeptide (PACAP-38) plays an inhibitory role against inflammation induced by chemical damage to zebrafish hair cells.
  3. study reveals the distribution of immunoreactive GHRH-like peptide in structures of the zebrafish brain; results suggest involvement of GHRH-LP in both neuroendocrine and feeding-associated nervous circuits
    Title: Distribution of growth hormone-releasing hormone-like peptide: Immunoreactivity in the central nervous system of the adult zebrafish (Danio rerio).
  4. expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development
    Title: Role of two genes encoding PACAP in early brain development in zebrafish.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC101522

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pituitary adenylate cyclase activating polypeptide activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenylate cyclase activating polypeptide 1b
Names
(zf)PACAP38-2
PACAP38-2
growth hormone-releasing hormone

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272081.1 → NP_001259010.1  adenylate cyclase activating polypeptide 1b isoform 2 precursor

    See identical proteins and their annotated locations for NP_001259010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX927088, EH439402
    UniProtKB/TrEMBL
    A0A8M1P449, Q5XJ02
    Related
    ENSDARP00000060811.4, ENSDART00000060812.5
    Conserved Domains (1) summary
    pfam00123
    Location:96 → 122
    Hormone_2; Peptide hormone

  2. NM_214715.2 → NP_999880.1  adenylate cyclase activating polypeptide 1b isoform 1 precursor

    See identical proteins and their annotated locations for NP_999880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BX927088, EH442184
    UniProtKB/TrEMBL
    A0A2R8Q4S7, B2GQT7, Q98TU3
    Related
    ENSDARP00000033245.5, ENSDART00000034784.7
    Conserved Domains (1) summary
    pfam00123
    Location:131 → 157
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31297150..31302661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous