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fuca1.1 alpha-L-fucosidase 1, tandem duplicate 1 [ Danio rerio (zebrafish) ]

Gene ID: 335494, updated on 27-Mar-2024

Summary

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Official Symbol
fuca1.1provided by ZNC
Official Full Name
alpha-L-fucosidase 1, tandem duplicate 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-7434
See related
Ensembl:ENSDARG00000035890 AllianceGenome:ZFIN:ZDB-GENE-030131-7434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fuca1; wu:fj17c05
Summary
Predicted to enable alpha-L-fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in lysosome. Is expressed in several structures, including EVL; epidermis; periderm; sensory system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 19
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (32495419..32500258, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (32908299..32913138, complement)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene guanosine monophosphate reductase Neighboring gene alpha-L-fucosidase 1, tandem duplicate 2 Neighboring gene zinc finger and BTB domain containing 8B Neighboring gene hes related family bHLH transcription factor with YRPW motif like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential expression of the duplicated cellular retinoic acid-binding protein 2 genes (crabp2a and crabp2b) during zebrafish embryonic development. Sharma MK, et al. Gene Expr Patterns, 2005 Feb. PMID 15661643
  2. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Mercer SE, et al. Dev Biol, 2013 Oct 15. PMID 23939298, Free PMC Article
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables alpha-L-fucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-L-fucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-L-fucosidase 1, tandem duplicate 1
Names
fucosidase, alpha-L- 1, tissue, tandem duplicate 1
NP_997905.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212740.1 → NP_997905.1  alpha-L-fucosidase 1, tandem duplicate 1 precursor

    See identical proteins and their annotated locations for NP_997905.1

    Status: PROVISIONAL

    Source sequence(s)
    BC050158
    UniProtKB/TrEMBL
    Q7ZW80
    Related
    ENSDARP00000052103.5, ENSDART00000052104.6
    Conserved Domains (3) summary
    smart00812
    Location:23 → 401
    Alpha_L_fucos; Alpha-L-fucosidase
    COG3669
    Location:51 → 371
    AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
    pfam16757
    Location:366 → 448
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    32495419..32500258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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