osbpl2b oxysterol binding protein-like 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: osbpl2bprovided by ZNC
Official Full Name: oxysterol binding protein-like 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6138
See related: Ensembl:ENSDARG00000013830 AllianceGenome:ZFIN:ZDB-GENE-030131-6138
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: osbpl2; Osbpl1a; zgc:55948; wu:fi36a04
Summary: Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including blastodisc; digestive system; nervous system; otic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to human OSBPL2 (oxysterol binding protein like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (9508531..9551967)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (9573568..9616997)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity.
Title: Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity.
Bioinformatics analysis indicates that zebrafish has two homologues of Osbpl2 gene (Osbpl2a and Osbpl2b) which have different expression patterns during embryonic development.
Title: Spatial and temporal expression patterns of Osbpl2a and Osbpl2b during zebrafish embryonic development.

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General gene information

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Markers

fi36a04.x1 (e-PCR)
- UniSTS:197378

kiaa0772 (e-PCR)
- UniSTS:205586

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cholesterol binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oxysterol-binding protein-related protein 2; oxysterol-binding protein-related protein 2b

Names: oxysterol binding protein-like 1A; oxysterol binding protein-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.