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Serpina7 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 [ Mus musculus (house mouse) ]

Gene ID: 331535, updated on 11-Apr-2024

Summary

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Official Symbol
Serpina7provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7provided by MGI
Primary source
MGI:MGI:3041197
See related
Ensembl:ENSMUSG00000031271 AllianceGenome:MGI:3041197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbg; C730040N12Rik
Summary
Predicted to enable hormone binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of endopeptidase activity; response to vitamin A; and thyroid hormone transport. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINA7 (serpin family A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 13.9), liver E14.5 (RPKM 1.1) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F1; X 61.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (137979998..137985985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (139079249..139085236, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene zinc finger CCCH type containing 14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47989 Neighboring gene RIKEN cDNA 4930513O06 gene Neighboring gene Nik related kinase Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern. Yan Z, et al. Gene, 2012 Sep 15. PMID 22820390
  2. Mice without macroH2A histone variants. Pehrson JR, et al. Mol Cell Biol, 2014 Dec. PMID 25312643, Free PMC Article
  3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern
    Title: Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in response to vitamin A ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thyroxine-binding globulin
Names
T4-binding globulin
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
serpin A7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382371.1 → NP_001369300.1  thyroxine-binding globulin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732419
    UniProtKB/Swiss-Prot
    A2RSG7, P61939
    Conserved Domains (1) summary
    cd19555
    Location:40 → 418
    serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

  2. NM_001382372.1 → NP_001369301.1  thyroxine-binding globulin isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732419
    UniProtKB/Swiss-Prot
    A2RSG7, P61939
    Conserved Domains (1) summary
    cd19555
    Location:40 → 418
    serpinA7_TBG; serpin family A member 7, thyroxine-binding globulin

  3. NM_177920.5 → NP_808588.3  thyroxine-binding globulin isoform 1 precursor

    See identical proteins and their annotated locations for NP_808588.3

    Status: VALIDATED

    Source sequence(s)
    AK050361, AK149459, BP767390, BY099279
    Consensus CDS
    CCDS53200.1
    UniProtKB/TrEMBL
    Q3UEL9
    Related
    ENSMUSP00000033626.9, ENSMUST00000033626.15
    Conserved Domains (1) summary
    cd02056
    Location:57 → 419
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    137979998..137985985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528579.3 → XP_006528642.1  thyroxine-binding globulin isoform X1

    UniProtKB/TrEMBL
    Q8BII9
    Related
    ENSMUSP00000056166.3, ENSMUST00000060824.4
    Conserved Domains (1) summary
    cl38926
    Location:3 → 249
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61939.1 GenPept UniProtKB/Swiss-Prot:P61939

Gene LinkOut

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