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Nek5 NIMA (never in mitosis gene a)-related expressed kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 330721, updated on 5-Mar-2024

Summary

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Official Symbol
Nek5provided by MGI
Official Full Name
NIMA (never in mitosis gene a)-related expressed kinase 5provided by MGI
Primary source
MGI:MGI:2142824
See related
Ensembl:ENSMUSG00000037738 AllianceGenome:MGI:2142824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6530411J22
Summary
Enables protein kinase activity. Acts upstream of or within positive regulation of cysteine-type endopeptidase activity and positive regulation of striated muscle cell differentiation. Is expressed in choroid invagination; diencephalon roof plate; medulla oblongata part of 4th ventricle choroid plexus; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human NEK5 (NIMA related kinase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 10.95 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22563631..22615443, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22073615..22125418, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, Cu++ transporting, beta polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E2858 Neighboring gene STARR-seq mESC enhancer starr_20897 Neighboring gene ALG11 alpha-1,2-mannosyltransferase Neighboring gene STARR-seq mESC enhancer starr_20898 Neighboring gene predicted gene, 57529 Neighboring gene STARR-seq mESC enhancer starr_20899 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 3 Neighboring gene STARR-seq mESC enhancer starr_20900 Neighboring gene STARR-seq mESC enhancer starr_20901 Neighboring gene cytoskeleton associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NEK5 regulates cell cycle progression during mouse oocyte maturation and preimplantation embryonic development. Li YY, et al. Mol Reprod Dev, 2019 Sep. PMID 31304658
  2. Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity. Shimizu K, et al. FEBS Lett, 2013 Jul 11. PMID 23727203
  3. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
  4. Novel gene function revealed by mouse mutagenesis screens for models of age-related disease. Potter PK, et al. Nat Commun, 2016 Aug 18. PMID 27534441, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nek5 promotes myogenic differentiation through up-regulation of caspase-3 activity.
    Title: Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek5
Names
never in mitosis A-related kinase 5
nimA-related protein kinase 5
NP_001334247.1
NP_808566.2
XP_006509217.1
XP_006509218.1
XP_006509222.1
XP_011240445.1
XP_011240446.1
XP_011240447.1
XP_011240448.1
XP_011240449.1
XP_011240451.1
XP_017168352.1
XP_030099482.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347318.2 → NP_001334247.1  serine/threonine-protein kinase Nek5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (2) has a distinct and longer C-terminus, compared to isoform 1.
    Source sequence(s)
    AK032672, AK054168, BC053516
    Consensus CDS
    CCDS85511.1
    UniProtKB/Swiss-Prot
    Q7TSC3, Q8C6N6, Q8CCJ0
    Related
    ENSMUSP00000148211.2, ENSMUST00000209656.2

  2. NM_177898.5 → NP_808566.2  serine/threonine-protein kinase Nek5 isoform 1

    See identical proteins and their annotated locations for NP_808566.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK032672, AK054168
    Consensus CDS
    CCDS52518.1
    UniProtKB/Swiss-Prot
    Q7TSC3
    Related
    ENSMUSP00000126705.2, ENSMUST00000169834.2
    Conserved Domains (2) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5
    smart00220
    Location:4 → 255
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22563631..22615443 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242145.3 → XP_011240447.1  serine/threonine-protein kinase Nek5 isoform X6

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  2. XM_006509155.5 → XP_006509218.1  serine/threonine-protein kinase Nek5 isoform X3

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  3. XM_030243622.2 → XP_030099482.1  serine/threonine-protein kinase Nek5 isoform X4

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  4. XM_011242144.3 → XP_011240446.1  serine/threonine-protein kinase Nek5 isoform X5

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  5. XM_011242146.4 → XP_011240448.1  serine/threonine-protein kinase Nek5 isoform X9

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  6. XM_011242149.4 → XP_011240451.1  serine/threonine-protein kinase Nek5 isoform X11

  7. XM_006509154.4 → XP_006509217.1  serine/threonine-protein kinase Nek5 isoform X1

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  8. XM_011242143.3 → XP_011240445.1  serine/threonine-protein kinase Nek5 isoform X2

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  9. XM_017312863.3 → XP_017168352.1  serine/threonine-protein kinase Nek5 isoform X7

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  10. XM_006509159.5 → XP_006509222.1  serine/threonine-protein kinase Nek5 isoform X8

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

  11. XM_011242147.3 → XP_011240449.1  serine/threonine-protein kinase Nek5 isoform X10

    Conserved Domains (1) summary
    cd08225
    Location:3 → 255
    STKc_Nek5; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5

RNA

  1. XR_003947310.2 RNA Sequence

  2. XR_004934846.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSC3.1 GenPept UniProtKB/Swiss-Prot:Q7TSC3

Gene LinkOut

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