usp36 ubiquitin specific peptidase 36 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: usp36provided by ZNC
Official Full Name: ubiquitin specific peptidase 36provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5450
See related: Ensembl:ENSDARG00000032327 AllianceGenome:ZFIN:ZDB-GENE-030131-5450
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: usp37; wu:fd19b04
Summary: Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Acts upstream of or within cranial skeletal system development. Predicted to be active in cytosol and nucleus. Orthologous to human USP36 (ubiquitin specific peptidase 36). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (57583653..57630811, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (57513129..57560267, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb80e06.x1 (e-PCR)
- UniSTS:191561

fb80e06.x1 (e-PCR)
- UniSTS:191562

AI722497 (e-PCR)
- UniSTS:206005

fd19b04.x1 (e-PCR)
- UniSTS:204237

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 36

NP_001292509.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305580.1 → NP_001292509.1 ubiquitin carboxyl-terminal hydrolase 36

Status: VALIDATED

Source sequence(s)

CT573423

UniProtKB/TrEMBL

A0A8M1P6D7, E7F4C0

Related

ENSDARP00000111119.2, ENSDART00000129598.3

Conserved Domains (4) summary

cd02661
Location:121 → 421

Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl19000
Location:888 → 1090

Cas10_III; CRISPR/Cas system-associated protein Cas10

pfam00443
Location:122 → 420

UCH; Ubiquitin carboxyl-terminal hydrolase

pfam15279
Location:610 → 746

SOBP; Sine oculis-binding protein