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Nup153 Nucleoporin 153kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32630, updated on 8-Apr-2024

Summary

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Official Symbol
Nup153provided by FlyBase
Official Full Name
Nucleoporin 153kDprovided by FlyBase
Primary source
FLYBASE:FBgn0061200
Locus tag
Dmel_CG4453
See related
AllianceGenome:FB:FBgn0061200
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4453; Dmel\CG4453; dmNup153; dNup153; Nup 153; nup153; NUP153
Summary
Enables chromatin DNA binding activity. A structural constituent of nuclear pore. Involved in several processes, including NLS-bearing protein import into nucleus; chromatin organization; and nuclear pore organization. Located in euchromatin; nuclear envelope; and nuclear periphery. Part of nuclear pore central transport channel. Is expressed in cyst progenitor cell; male germline stem cell; and spermatozoon. Orthologous to human NUP153 (nucleoporin 153). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
14F2-14F2; 1-54 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16599241..16610459)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16493274..16504492)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Structural maintenance of chromosomes 3 Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene uncharacterized protein Neighboring gene mir-4965 stem loop Neighboring gene stable intronic sequence RNA 2 Neighboring gene mushroom bodies tiny Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA association defines a functionally conserved domain in the nuclear pore protein Nup153. Dimaano C, et al. J Biol Chem, 2001 Nov 30. PMID 11567018
  2. Molecular Evolution of Drosophila Germline Stem Cell and Neural Stem Cell Regulating Genes. Choi JY, et al. Genome Biol Evol, 2015 Oct 27. PMID 26507797, Free PMC Article
  3. Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome. Vaquerizas JM, et al. PLoS Genet, 2010 Feb 12. PMID 20174442, Free PMC Article
  4. A novel method to detect proteins evolving at correlated rates: identifying new functional relationships between coevolving proteins. Clark NL, et al. Mol Biol Evol, 2010 May. PMID 20044587, Free PMC Article
  5. Evolution. Two rapidly evolving genes spell trouble for hybrids. Pennisi E. Science, 2006 Nov 24. PMID 17124304

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb.
    Title: Nuclear pore proteins nup153 and megator define transcriptionally active regions in the Drosophila genome.
  2. The FG repeats of Nup153 are necessary for its function in transport, whereas the remainder of the protein maintains pore integrity.
    Title: Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sex-chromosome dosage compensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore central transport channel IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nucleoporin 153kD
Names
CG4453-PA
CG4453-PC
CG4453-PD
Nup153-PA
Nup153-PC
Nup153-PD
nucleoporin 153

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16599241..16610459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144734.2 → NP_001138206.1  nucleoporin 153kD, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138206.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1LZ48, Q9VXE6
    Conserved Domains (4) summary
    smart00547
    Location:1239 → 1261
    ZnF_RBZ; Zinc finger domain
    sd00025
    Location:864 → 883
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:1009 → 1038
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:458 → 910
    Nup153; Nucleoporin Nup153-like

  2. NM_001103532.3 → NP_001097002.1  nucleoporin 153kD, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097002.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JV18
    Conserved Domains (4) summary
    smart00547
    Location:1239 → 1261
    ZnF_RBZ; Zinc finger domain
    sd00025
    Location:864 → 883
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:1009 → 1038
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:458 → 910
    Nup153; Nucleoporin Nup153-like

  3. NM_132908.5 → NP_573136.3  nucleoporin 153kD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573136.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1LZ48, Q9VXE6
    Conserved Domains (4) summary
    smart00547
    Location:1239 → 1261
    ZnF_RBZ; Zinc finger domain
    sd00025
    Location:864 → 883
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:1009 → 1038
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam08604
    Location:458 → 910
    Nup153; Nucleoporin Nup153-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1YKA1 A1YKA1
A1YKA3 A1YKA3
A1YKA5 A1YKA5
A1YKA7 A1YKA7
A1YKA8 A1YKA8
A1YKB1 A1YKB1
A8JV18 A8JV18
Q95SX4 Q95SX4
Q960L2 Q960L2
Q9VXE6.4 Q9VXE6

Gene LinkOut

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