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CG32075 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 326192, updated on 4-Apr-2024

Summary

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Official Symbol
CG32075provided by FlyBase
Primary source
FLYBASE:FBgn0052075
Locus tag
Dmel_CG32075
See related
AllianceGenome:FB:FBgn0052075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6316; Dmel\CG32075
Summary
Predicted to enable endonuclease activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Human ortholog(s) of this gene implicated in Wilson-Turner syndrome. Orthologous to human LAS1L (LAS1 like ribosome biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
68A3-68A4; 3-34 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11062726..11064941, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11055826..11058041, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Biogenesis of lysosome-related organelles complex 1, subunit 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of the SuUR gene on intercalary heterochromatin in Drosophila melanogaster polytene chromosomes. Zhimulev IF, et al. Chromosoma, 2003 Mar. PMID 12644953
  2. Transcripts immunoprecipitated with Sxl protein in primordial germ cells of Drosophila embryos. Ota R, et al. Dev Growth Differ, 2017 Dec. PMID 29124738
  3. The Drosophila suppressor of underreplication protein binds to late-replicating regions of polytene chromosomes. Makunin IV, et al. Genetics, 2002 Mar. PMID 11901119, Free PMC Article
  4. The pentameric nucleoplasmin fold is present in Drosophila FKBP39 and a large number of chromatin-related proteins. Edlich-Muth C, et al. J Mol Biol, 2015 May 22. PMID 25813344, Free PMC Article
  5. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of 5.8S rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Las1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32075-PA
CG32075-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11062726..11064941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140171.4 → NP_648428.1  uncharacterized protein Dmel_CG32075, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648428.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY9
    Related
    FBpp0075969
    Conserved Domains (1) summary
    pfam04031
    Location:42 → 186
    Las1; Las1-like

  2. NM_001259783.1 → NP_001246712.1  uncharacterized protein Dmel_CG32075, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246712.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZY9
    Conserved Domains (1) summary
    pfam04031
    Location:42 → 186
    Las1; Las1-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SZY9 Q8SZY9

Gene LinkOut

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