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abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [ Danio rerio (zebrafish) ]

Gene ID: 323301, updated on 25-Apr-2024

Summary

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Official Symbol
abcc3provided by ZNC
Official Full Name
ATP-binding cassette, sub-family C (CFTR/MRP), member 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-050517-16
See related
Ensembl:ENSDARG00000096662 AllianceGenome:ZFIN:ZDB-GENE-050517-16
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb94e12
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (695358..788154)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (689417..782211)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 2, cytosolic sulfotransferase 2 Neighboring gene Ras association and DIL domains 2b Neighboring gene WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2b Neighboring gene transducer of ERBB2, 1b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. MRP proteins as potential mediators of heavy metal resistance in zebrafish cells. Long Y, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2011 Apr. PMID 21147257
  2. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
  3. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ABC-type glutathione S-conjugate transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    695358..788154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306375.3 → XP_009304650.1  canalicular multispecific organic anion transporter 2 isoform X5

    UniProtKB/TrEMBL
    A0A8M3BDY5
    Conserved Domains (4) summary
    cd03250
    Location:640 → 841
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:314 → 863
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:330 → 595
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:985 → 1107
    ABC_membrane; ABC transporter transmembrane region

  2. XM_009306374.3 → XP_009304649.1  canalicular multispecific organic anion transporter 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AY17
    Conserved Domains (4) summary
    cd03250
    Location:640 → 841
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:314 → 863
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam00664
    Location:330 → 595
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:993 → 1139
    ABC_membrane; ABC transporter transmembrane region

  3. XM_009306372.3 → XP_009304647.1  canalicular multispecific organic anion transporter 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3B4C9
    Related
    ENSDARP00000139878.1, ENSDART00000161691.2
    Conserved Domains (4) summary
    TIGR00957
    Location:10 → 1538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1299 → 1519
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:640 → 841
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:985 → 1252
    ABC_membrane; ABC transporter transmembrane region

  4. XM_009306370.3 → XP_009304645.1  canalicular multispecific organic anion transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AXY3
    Conserved Domains (4) summary
    TIGR00957
    Location:10 → 1539
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1300 → 1520
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:640 → 841
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:330 → 595
    ABC_membrane; ABC transporter transmembrane region

  5. XM_009306371.3 → XP_009304646.1  canalicular multispecific organic anion transporter 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B758
    Conserved Domains (4) summary
    TIGR00957
    Location:10 → 1538
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
    cd03244
    Location:1299 → 1519
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:639 → 840
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    pfam00664
    Location:329 → 594
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. XR_002459730.1 RNA Sequence

  2. XR_662993.3 RNA Sequence

Nucleotide Protein Strain
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