atp6v0d1 ATPase H+ transporting V0 subunit d1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp6v0d1provided by ZNC
Official Full Name: ATPase H+ transporting V0 subunit d1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1531
See related: Ensembl:ENSDARG00000069090 AllianceGenome:ZFIN:ZDB-GENE-030131-1531
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb73h07; zgc:63769; wu:fb73h07
Summary: Predicted to enable proton transmembrane transporter activity. Involved in cilium assembly and left/right axis specification. Acts upstream of or within several processes, including animal organ development; apical protein localization; and pigment granule organization. Predicted to be located in lysosome and membrane. Predicted to be part of plasma membrane proton-transporting V-type ATPase complex and vacuolar proton-transporting V-type ATPase complex. Predicted to be active in early endosome. Predicted to colocalize with centrosome. Is expressed in several structures, including digestive system; integument; nervous system; pleuroperitoneal region; and presumptive retinal pigmented epithelium. Orthologous to human ATP6V0D1 (ATPase H+ transporting V0 subunit d1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (35086396..35094933)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (34814919..34823456)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Self-organization of apical membrane protein sorting in epithelial cells.
Title: Self-organization of apical membrane protein sorting in epithelial cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to increased oxygen levels	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in left/right axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuromast hair cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to copper ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
colocalizes_with centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of plasma membrane proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: V-type proton ATPase subunit d 1

Names: ATPase, H+ transporting, V0 subunit D; ATPase, H+ transporting, lysosomal V0 subunit d1; V-ATPase subunit d 1; cto; vacuolar proton pump subunit d 1

NP_955914.1

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199620.1 → NP_955914.1 V-type proton ATPase subunit d 1

See identical proteins and their annotated locations for NP_955914.1

Status: PROVISIONAL

Source sequence(s)

BC056822

UniProtKB/Swiss-Prot

Q6PGV1

Related

ENSDARP00000091027.3, ENSDART00000100254.5

Conserved Domains (2) summary

COG1527
Location:13 → 349

NtpC; Archaeal/vacuolar-type H+-ATPase subunit C/Vma6 [Energy production and conversion]

pfam01992
Location:15 → 344

vATP-synt_AC39; ATP synthase (C/AC39) subunit