fah fumarylacetoacetate hydrolase (fumarylacetoacetase) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fahprovided by ZNC
Official Full Name: fumarylacetoacetate hydrolase (fumarylacetoacetase)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1091
See related: Ensembl:ENSDARG00000101762 AllianceGenome:ZFIN:ZDB-GENE-030131-1091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb59b12; zgc:55316; wu:fb59b12
Summary: Predicted to enable fumarylacetoacetase activity. Predicted to be involved in L-phenylalanine catabolic process; homogentisate catabolic process; and tyrosine catabolic process. Predicted to act upstream of or within aromatic amino acid family metabolic process. Is expressed in epidermis; fin; head mesenchyme; liver; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (10589010..10633609)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (10424673..10447782, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fumarylacetoacetase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarylacetoacetase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in homogentisate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tyrosine catabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fumarylacetoacetase

NP_955895.1

EC 3.7.1.2

XP_021333072.1

EC 3.7.1.2

XP_021333073.1

EC 3.7.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199601.1 → NP_955895.1 fumarylacetoacetase

See identical proteins and their annotated locations for NP_955895.1

Status: PROVISIONAL

Source sequence(s)

BC044366

UniProtKB/TrEMBL

Q6NY55, Q803S0

Related

ENSDARP00000149145.1, ENSDART00000182624.1

Conserved Domains (2) summary

pfam01557
Location:54 → 330

FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family

pfam09298
Location:1 → 48

FAA_hydrolase_N; Fumarylacetoacetase N-terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

10589010..10633609

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477398.1 → XP_021333073.1 fumarylacetoacetase isoform X1

UniProtKB/TrEMBL

A0A8M9PNK3

Conserved Domains (1) summary

TIGR01266
Location:30 → 444

fum_ac_acetase; fumarylacetoacetase
XM_021477397.1 → XP_021333072.1 fumarylacetoacetase isoform X1

UniProtKB/TrEMBL

A0A8M9PNK3

Conserved Domains (1) summary

TIGR01266
Location:30 → 444

fum_ac_acetase; fumarylacetoacetase