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ist1 IST1 factor associated with ESCRT-III [ Danio rerio (zebrafish) ]

Gene ID: 321460, updated on 27-Mar-2024

Summary

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Official Symbol
ist1provided by ZNC
Official Full Name
IST1 factor associated with ESCRT-IIIprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-179
See related
Ensembl:ENSDARG00000051888 AllianceGenome:ZFIN:ZDB-GENE-030131-179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb16b04; zgc:55671; wu:fb16b04; wu:fi89e07
Summary
Acts upstream of or within axon extension and endosome organization. Predicted to be located in nuclear envelope. Is expressed in female organism. Orthologous to human IST1 (IST1 factor associated with ESCRT-III). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56472546..56484798)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56171151..56183387)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100536797 Neighboring gene solute carrier family 22 member 31 Neighboring gene uncharacterized LOC110439948 Neighboring gene polycystic kidney disease 1-like 3 Neighboring gene uncharacterized LOC110439902

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. Allison R, et al. J Cell Biol, 2013 Aug 5. PMID 23897888, Free PMC Article
  2. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IST1 homolog
Names
KIAA0174-like protein
increased sodium tolerance 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328509.1 → NP_001315438.1  IST1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR382281, CR848662, EH443906
    UniProtKB/TrEMBL
    A0A8M1P500, F1R0S8
    Related
    ENSDARP00000116734.1, ENSDART00000135259.3
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 176
    Ist1; Regulator of Vps4 activity in the MVB pathway

  2. NM_212585.2 → NP_997750.1  IST1 homolog isoform 1

    See identical proteins and their annotated locations for NP_997750.1

    Status: VALIDATED

    Source sequence(s)
    CR382281, CR848662, EH443906, EH504842
    UniProtKB/TrEMBL
    A0A8M1PH49, Q7ZVT1
    Related
    ENSDARP00000068086.5, ENSDART00000073596.7
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 176
    Ist1; Regulator of Vps4 activity in the MVB pathway

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    56472546..56484798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477395.1 → XP_021333070.1  IST1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M1PH49, Q7ZVT1
    Conserved Domains (1) summary
    pfam03398
    Location:13 → 176
    Ist1; Regulator of Vps4 activity in the MVB pathway
Nucleotide Protein Strain
Heading Accession and Version

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